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Measurement of cellular excitability by whole cell patch clamp technique

M. Karmažínová, Ľ. Lacinová

. 2010 ; 59 (Suppl. 1) : S1-S7.
. 2010 ; 59 (Suppl. 1) : S1-S7.

Jazyk angličtina Země Česko

Typ dokumentu přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc11004378

Patch clamp method developed more than 30 years ago is widely used for investigation of cellular excitability manifested as transmembrane ionic current and/or generation of action potentials. This technique could be applied to measurement of ionic currents flowing through individual (single) ion channels or through the whole assembly of ion channels expressed in the whole cell. Whole cell configuration is more common for measurement of ion currents and the only one enabling measurement of action potentials. This method allows detailed analysis of mechanisms and structural determinants of voltagedependent gating of ion channels as well as regulation of channel activity by intracellular signaling pathways and pharmacological agents.

Citace poskytuje Crossref.org

Methods in Experimental and Clinical Cardiovascular Research. 37th Workshop of the Committee of Experimental Cardiology, Blansko, 2010

Bibliografie atd.

Lit.: 6

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