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Measurement of cellular excitability by whole cell patch clamp technique
M. Karmažínová, Ľ. Lacinová
Language English Country Czech Republic
Document type Review
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- MeSH
- Action Potentials MeSH
- Models, Biological MeSH
- Cell Membrane metabolism MeSH
- Financing, Organized MeSH
- Ion Channel Gating MeSH
- Ion Channels metabolism MeSH
- Humans MeSH
- Membrane Potentials MeSH
- Patch-Clamp Techniques MeSH
- Calcium Signaling MeSH
- Calcium Channels, T-Type metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Review MeSH
Patch clamp method developed more than 30 years ago is widely used for investigation of cellular excitability manifested as transmembrane ionic current and/or generation of action potentials. This technique could be applied to measurement of ionic currents flowing through individual (single) ion channels or through the whole assembly of ion channels expressed in the whole cell. Whole cell configuration is more common for measurement of ion currents and the only one enabling measurement of action potentials. This method allows detailed analysis of mechanisms and structural determinants of voltagedependent gating of ion channels as well as regulation of channel activity by intracellular signaling pathways and pharmacological agents.
References provided by Crossref.org
Methods in Experimental and Clinical Cardiovascular Research. 37th Workshop of the Committee of Experimental Cardiology, Blansko, 2010
Bibliography, etc.Lit.: 6
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