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Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis
Yvonne Benešová, Anna Vašků, Pavel Šťourač, Magdalena Hladíková, Michal Beránek, Zdeněk Kadaňka, Hana Novotná, Josef Bednařík
Language English Country Netherlands
Document type Research Support, Non-U.S. Gov't
Grant support
NR8832
MZ0
CEP Register
Digital library NLK
Full text - Část
Source
NLK
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- Adult MeSH
- Gene Frequency MeSH
- Genetic Predisposition to Disease MeSH
- Genotype MeSH
- Confidence Intervals MeSH
- Middle Aged MeSH
- Humans MeSH
- Matrix Metalloproteinase 2 genetics blood MeSH
- Matrix Metalloproteinase 9 genetics MeSH
- Odds Ratio MeSH
- Polymorphism, Genetic genetics MeSH
- Multiple Sclerosis genetics MeSH
- Sex Factors MeSH
- Case-Control Studies MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
We investigated the association of matrix metalloproteinase-9 (-1562C/T, +279R/Q) and matrix metalloproteinase-2 (-1575G/A, -1306C/T) gene polymorphisms with multiple sclerosis (MS) susceptibility, gender differences and disability in 244 patients and 132 healthy subjects. A significant decrease of the -1562T allele carriers in MS patients compared to controls (Pa=0.01, Pacorr=0.05) in -1562C/T MMP-9 gene polymorphism was found, (odds ratio (OR) -0.58, 95% confidence interval (CI):0.38-0.89). Significant differences were also demonstrated between female patients and healthy females (Pa=0.01, Pacorr=0.05), (OR-0.53, 95% CI:0.32-0.86). Other polymorphisms were not associated either with MS susceptibility or with phenotype of the disease. No association with disability was found.
Department of Clinical Biochemistry and Hematology University Hospital Brno Brno Czech Republic
Department of Pathological physiology Faculty of Medicine Masaryk University Brno Czech Republic
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- $a Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis / $c Yvonne Benešová, Anna Vašků, Pavel Šťourač, Magdalena Hladíková, Michal Beránek, Zdeněk Kadaňka, Hana Novotná, Josef Bednařík
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- $a Department of Neurology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic. beneivo@seznam.cz
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- $a We investigated the association of matrix metalloproteinase-9 (-1562C/T, +279R/Q) and matrix metalloproteinase-2 (-1575G/A, -1306C/T) gene polymorphisms with multiple sclerosis (MS) susceptibility, gender differences and disability in 244 patients and 132 healthy subjects. A significant decrease of the -1562T allele carriers in MS patients compared to controls (Pa=0.01, Pacorr=0.05) in -1562C/T MMP-9 gene polymorphism was found, (odds ratio (OR) -0.58, 95% confidence interval (CI):0.38-0.89). Significant differences were also demonstrated between female patients and healthy females (Pa=0.01, Pacorr=0.05), (OR-0.53, 95% CI:0.32-0.86). Other polymorphisms were not associated either with MS susceptibility or with phenotype of the disease. No association with disability was found.
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