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RANK ligand, jeho role při vzniku CTIBL a význam jeho inhibice
[RANK ligand, its role in the development of CTIBL and importance of its inhibition]
Študent V.
Status neindexováno Jazyk čeština Země Česko
Typ dokumentu abstrakty
Androgen deprivation therapy is standard first line therapy in prostate cancer patients. It is used for its proven anticancer efficacy, has however a negative impact on bone heatlh. Osteoclasts are bone cells responsible for osteoresorption. Key mediator for their differentiation, maturation, activity and survival is the RANKL (receptor activator of nuclear factor kappa B ligand) produced by osteoblasts. Osteoprotegerin is soluble receptor binding RANKL. Hormon ablation decreases estrogen level thus causing cancer treatment bone loss (CTIBL) by down regulation of protegerin production. Relative over-abundance of RANKL leads to decreased bone mineral density (BMD) which predispones patients for pathological fractures. New therapeutic option use the mechanism of RANKL inhibition.
RANK ligand, its role in the development of CTIBL and importance of its inhibition
10. zimní urologické sympozium, Špindlerův Mlýn, 9.-15. ledna 2011
Bibliografie atd.Lit.: 4
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