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MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders
L. Hollá, F. Mrázek, M. Petřek
Jazyk angličtina Země Velká Británie
E-zdroje NLK
Medline Complete (EBSCOhost) od 2005-02-01 do Před 1 rokemWiley Online Library (archiv) od 1997-01-01 do 2012-12-31
- MeSH
- alely MeSH
- alergie epidemiologie genetika MeSH
- chemokin CCL2 genetika MeSH
- dospělí MeSH
- financování organizované MeSH
- frekvence genu MeSH
- genotyp MeSH
- lidé středního věku MeSH
- lidé MeSH
- polymorfismus genetický MeSH
- receptory CCR2 genetika MeSH
- studie případů a kontrol MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Geografické názvy
- Česká republika MeSH
Several lines of evidence suggest that chemokines play an important role in asthma and allergy. We analysed polymorphisms at -2518A/G and -2076A/T of MCP-1 and V64I of CCR2 gene in healthy subjects (n = 306) and allergic patients (n = 332). Allele and genotype frequencies did not differ significantly between groups. Nevertheless, MCP-1 variants were associated with allergen sensitization. The results suggest that MCP-1, but not CCR2 gene variants, may participate in the pathogenesis of allergic phenotypes at least in the Caucasian population.
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- $a Several lines of evidence suggest that chemokines play an important role in asthma and allergy. We analysed polymorphisms at -2518A/G and -2076A/T of MCP-1 and V64I of CCR2 gene in healthy subjects (n = 306) and allergic patients (n = 332). Allele and genotype frequencies did not differ significantly between groups. Nevertheless, MCP-1 variants were associated with allergen sensitization. The results suggest that MCP-1, but not CCR2 gene variants, may participate in the pathogenesis of allergic phenotypes at least in the Caucasian population.
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