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Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines

Renata Veselská, Marketa Hermanová, Tomáš Loja, Petr Chlapek, Iva Zambo, Karel Veselý, Karel Zitterbart, Jaroslav Štěrba

. 2008 ; 8 (300) : 1-8.

Jazyk angličtina Země Velká Británie

Perzistentní odkaz   https://www.medvik.cz/link/bmc11009974

Grantová podpora
NR9125 MZ0 CEP - Centrální evidence projektů

BACKGROUND: Nestin was originally identified as a class VI intermediate filament protein that is expressed in stem cells and progenitor cells in the mammalian CNS during development. This protein is replaced in the adult organism by other intermediate filament proteins; however, nestin may be re-expressed under certain pathological conditions such as ischemia, inflammation, brain injury, and neoplastic transformation. Nestin has been detected in many kinds of tumors, especially in tumors derived from the CNS. Co-expression of nestin and the CD133 surface molecule is considered to be a marker for cancer stem cells in neurogenic tumors. Our work was aimed at a detailed study of nestin expression in osteosarcomas and osteosarcoma-derived cell lines.

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$a Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines / $c Renata Veselská, Marketa Hermanová, Tomáš Loja, Petr Chlapek, Iva Zambo, Karel Veselý, Karel Zitterbart, Jaroslav Štěrba
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$a Laboratory of Tumor Biology and Genetics, Institute of Experimental Biology, School of Science, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic. veselska@sci.muni.cz
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$a BACKGROUND: Nestin was originally identified as a class VI intermediate filament protein that is expressed in stem cells and progenitor cells in the mammalian CNS during development. This protein is replaced in the adult organism by other intermediate filament proteins; however, nestin may be re-expressed under certain pathological conditions such as ischemia, inflammation, brain injury, and neoplastic transformation. Nestin has been detected in many kinds of tumors, especially in tumors derived from the CNS. Co-expression of nestin and the CD133 surface molecule is considered to be a marker for cancer stem cells in neurogenic tumors. Our work was aimed at a detailed study of nestin expression in osteosarcomas and osteosarcoma-derived cell lines.
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$a Hermanová, Markéta $7 xx0073982 $u 1st Institute of Pathologic Anatomy, St. Anne's University Hospital, Brno, Czech Republic; Institute of Pathology, University Hospital Brno, Brno, Czech Republic
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$a Loja, Tomáš $7 xx0112989 $u Laboratory of Tumor Biology and Genetics, Institute of Experimental Biology, School of Science, Masaryk University, Brno, Czech Republic
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