The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.

Annotation

note category: an aspect of bone physiol

DUI

D016723 MeSH Browser

CUI

M0025466

Previous indexing

Bone Development (1967-1991); Bone Regeneration (1967-1991); Bone Resorption (1967-1991)

History note

92

Public note

92