-
Something wrong with this record ?
MicroRNA involvement in glioblastoma pathogenesis
J. Nováková, O. Slabý, R. Vyzula, J. Michálek
Language English Country United States
Document type Review, Research Support, Non-U.S. Gov't
Grant support
NS9875
MZ0
CEP Register
Digital library NLK
Full text - Article
Source
NLK
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- Gliosarcoma metabolism MeSH
- Humans MeSH
- MicroRNAs physiology genetics classification MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of microRNA regulatory network is one of the key mechanisms in glioblastoma pathogenesis. MicroRNA deregulation is involved in processes such as cell proliferation, apoptosis, cell cycle regulation, invasion, glioma stem cell behavior, and angiogenesis. In this review, we summarize the current knowledge of miRNA functions in glioblastoma with an emphasis on its significance in glioblastoma oncogenic signaling and its potential to serve as a disease biomarker and a novel therapeutic target in oncology.
- 000
- 01994naa 2200301 a 4500
- 001
- bmc11016805
- 003
- CZ-PrNML
- 005
- 20140814120934.0
- 008
- 110628s2009 xxu e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Nováková, Jana. $7 _AN063417
- 245 10
- $a MicroRNA involvement in glioblastoma pathogenesis / $c J. Nováková, O. Slabý, R. Vyzula, J. Michálek
- 314 __
- $a University Cell Immunotherapy Center, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
- 520 9_
- $a MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of microRNA regulatory network is one of the key mechanisms in glioblastoma pathogenesis. MicroRNA deregulation is involved in processes such as cell proliferation, apoptosis, cell cycle regulation, invasion, glioma stem cell behavior, and angiogenesis. In this review, we summarize the current knowledge of miRNA functions in glioblastoma with an emphasis on its significance in glioblastoma oncogenic signaling and its potential to serve as a disease biomarker and a novel therapeutic target in oncology.
- 590 __
- $a bohemika - dle Pubmed
- 650 _2
- $a gliosarkom $x metabolismus $7 D018316
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mikro RNA $x fyziologie $x genetika $x klasifikace $7 D035683
- 655 _2
- $a přehledy $7 D016454
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Slabý, Ondřej, $d 1981- $7 js20030220015
- 700 1_
- $a Vyzula, Rostislav, $d 1952- $7 nlk20000083661
- 700 1_
- $a Michálek, Jaroslav $7 xx0071617
- 773 0_
- $t Biochemical & Biophysical Research Communications $w MED00009307 $g Roč. 386, č. 1 (2009), s. 1-5
- 910 __
- $a ABA008 $b x $y 2 $z 0
- 990 __
- $a 20110720121948 $b ABA008
- 991 __
- $a 20140814121304 $b ABA008
- 999 __
- $a ok $b bmc $g 864077 $s 726597
- BAS __
- $a 3
- BMC __
- $a 2009 $x MED00009307 $b 386 $c 1 $d 1-5 $m Biochemical and biophysical research communications $n Biochem Biophys Res Commun
- GRA __
- $a NS9875 $p MZ0
- LZP __
- $a 2011-3B09/BBjvme
