-
Something wrong with this record ?
Automated T-wave analysis can differentiate acquired QT prolongation from congenital long QT syndrome
A. Sugrue, PA. Noseworthy, V. Kremen, JM. Bos, B. Qiang, RK. Rohatgi, Y. Sapir, ZI. Attia, P. Brady, PJ. Caraballo, SJ. Asirvatham, PA. Friedman, MJ. Ackerman,
Language English Country United States
Document type Journal Article
NLK
PubMed Central
from 2001
Medline Complete (EBSCOhost)
from 2004-01-01
ROAD: Directory of Open Access Scholarly Resources
from 1996
PubMed
28429460
DOI
10.1111/anec.12455
Knihovny.cz E-resources
- MeSH
- Diagnosis, Differential MeSH
- Electrocardiography methods MeSH
- Humans MeSH
- Adolescent MeSH
- Retrospective Studies MeSH
- Aged MeSH
- Sensitivity and Specificity MeSH
- Long QT Syndrome congenital diagnosis physiopathology MeSH
- Check Tag
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
BACKGROUND: Prolongation of the QT on the surface electrocardiogram can be due to either genetic or acquired causes. Distinguishing congenital long QT syndrome (LQTS) from acquired QT prolongation has important prognostic and management implications. We aimed to investigate if quantitative T-wave analysis could provide a tool for the physician to differentiate between congenital and acquired QT prolongation. METHODS: Patients were identified through an institution-wide computer-based QT screening system which alerts the physician if the QTc ≥ 500 ms. ECGs were retrospectively analyzed with an automated T-wave analysis program. Congenital LQTS was compared in a 1:3 ratio to those with an identified acquired etiology for QT prolongation (electrolyte abnormality and/or prescription of known QT prolongation medications). Linear discriminant analysis was performed using 10-fold cross-validation to statistically test the selected features. RESULTS: The 12-lead ECG of 38 patients with congenital LQTS and 114 patients with drug-induced and/or electrolyte-mediated QT prolongation were analyzed. In lead V5 , patients with acquired QT prolongation had a shallower T wave right slope (-2,322 vs. -3,593 mV/s), greater T-peak-Tend interval (109 vs. 92 ms), and smaller T wave center of gravity on the x axis (290 ms vs. 310 ms; p < .001). These features could distinguish congenital from acquired causes in 77% of cases (sensitivity 90%, specificity 58%). CONCLUSION: T-wave morphological analysis on lead V5 of the surface ECG could successfully differentiate congenital from acquired causes of QT prolongation.
Department of Cardiovascular Diseases Division of Heart Rhythm Services Mayo Clinic Rochester MN USA
Department of Internal Medicine Mayo Clinic Rochester MN USA
Electrical and Computer Engineering Ben Gurion University of the Negev Beer Sheva Israel
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc18033930
- 003
- CZ-PrNML
- 005
- 20181022115933.0
- 007
- ta
- 008
- 181008s2017 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1111/anec.12455 $2 doi
- 035 __
- $a (PubMed)28429460
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Sugrue, Alan $u Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA. Department of Cardiovascular Diseases, Division of Heart Rhythm Services, Mayo Clinic, Rochester, MN, USA.
- 245 10
- $a Automated T-wave analysis can differentiate acquired QT prolongation from congenital long QT syndrome / $c A. Sugrue, PA. Noseworthy, V. Kremen, JM. Bos, B. Qiang, RK. Rohatgi, Y. Sapir, ZI. Attia, P. Brady, PJ. Caraballo, SJ. Asirvatham, PA. Friedman, MJ. Ackerman,
- 520 9_
- $a BACKGROUND: Prolongation of the QT on the surface electrocardiogram can be due to either genetic or acquired causes. Distinguishing congenital long QT syndrome (LQTS) from acquired QT prolongation has important prognostic and management implications. We aimed to investigate if quantitative T-wave analysis could provide a tool for the physician to differentiate between congenital and acquired QT prolongation. METHODS: Patients were identified through an institution-wide computer-based QT screening system which alerts the physician if the QTc ≥ 500 ms. ECGs were retrospectively analyzed with an automated T-wave analysis program. Congenital LQTS was compared in a 1:3 ratio to those with an identified acquired etiology for QT prolongation (electrolyte abnormality and/or prescription of known QT prolongation medications). Linear discriminant analysis was performed using 10-fold cross-validation to statistically test the selected features. RESULTS: The 12-lead ECG of 38 patients with congenital LQTS and 114 patients with drug-induced and/or electrolyte-mediated QT prolongation were analyzed. In lead V5 , patients with acquired QT prolongation had a shallower T wave right slope (-2,322 vs. -3,593 mV/s), greater T-peak-Tend interval (109 vs. 92 ms), and smaller T wave center of gravity on the x axis (290 ms vs. 310 ms; p < .001). These features could distinguish congenital from acquired causes in 77% of cases (sensitivity 90%, specificity 58%). CONCLUSION: T-wave morphological analysis on lead V5 of the surface ECG could successfully differentiate congenital from acquired causes of QT prolongation.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a diferenciální diagnóza $7 D003937
- 650 _2
- $a elektrokardiografie $x metody $7 D004562
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a syndrom dlouhého QT $x vrozené $x diagnóza $x patofyziologie $7 D008133
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a senzitivita a specificita $7 D012680
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Noseworthy, Peter A $u Department of Cardiovascular Diseases, Division of Heart Rhythm Services, Mayo Clinic, Rochester, MN, USA.
- 700 1_
- $a Kremen, Vaclav $u Department of Cardiovascular Diseases, Division of Heart Rhythm Services, Mayo Clinic, Rochester, MN, USA. Czech Institute of Informatics, Robotics, and Cybernetics, Czech Technical University in Prague, Prague, Czech Republic.
- 700 1_
- $a Bos, J Martijn $u Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN, USA. Department of Molecular Pharmacology & Experimental Therapeutics Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN, USA.
- 700 1_
- $a Qiang, Bo $u Department of Cardiovascular Diseases, Division of Heart Rhythm Services, Mayo Clinic, Rochester, MN, USA.
- 700 1_
- $a Rohatgi, Ram K $u Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN, USA.
- 700 1_
- $a Sapir, Yehu $u Electrical and Computer Engineering, Ben-Gurion University of the Negev, Beer Sheva, Israel.
- 700 1_
- $a Attia, Zachi I $u Department of Cardiovascular Diseases, Division of Heart Rhythm Services, Mayo Clinic, Rochester, MN, USA. Electrical and Computer Engineering, Ben-Gurion University of the Negev, Beer Sheva, Israel.
- 700 1_
- $a Brady, Peter $u Department of Cardiovascular Diseases, Division of Heart Rhythm Services, Mayo Clinic, Rochester, MN, USA.
- 700 1_
- $a Caraballo, Pedro J $u Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
- 700 1_
- $a Asirvatham, Samuel J $u Department of Cardiovascular Diseases, Division of Heart Rhythm Services, Mayo Clinic, Rochester, MN, USA. Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN, USA.
- 700 1_
- $a Friedman, Paul A $u Department of Cardiovascular Diseases, Division of Heart Rhythm Services, Mayo Clinic, Rochester, MN, USA.
- 700 1_
- $a Ackerman, Michael J $u Department of Cardiovascular Diseases, Division of Heart Rhythm Services, Mayo Clinic, Rochester, MN, USA. Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN, USA. Department of Molecular Pharmacology & Experimental Therapeutics Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN, USA.
- 773 0_
- $w MED00007642 $t Annals of noninvasive electrocardiology the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc $x 1542-474X $g Roč. 22, č. 6 (2017)
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/28429460 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20181008 $b ABA008
- 991 __
- $a 20181022120439 $b ABA008
- 999 __
- $a ok $b bmc $g 1339659 $s 1030924
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2017 $b 22 $c 6 $e 20170421 $i 1542-474X $m Annals of noninvasive electrocardiology $n Ann Noninvasive Electrocardiol $x MED00007642
- LZP __
- $a Pubmed-20181008
