-
Je něco špatně v tomto záznamu ?
Study of efficacy of reactivator HI 6 in reactivation of immobilized acetylcholinesterase, inhibited by organophosphorus chemical warfare agents of the "G" series
M. Hoskovcová, E. Halámek, Z. Kobliha
Jazyk angličtina Země Spojené státy americké
- MeSH
- acetylcholinesterasa metabolismus MeSH
- biosenzitivní techniky MeSH
- chemické bojové látky farmakologie MeSH
- chemické modely MeSH
- cholinesterasové inhibitory farmakologie MeSH
- enzymy imobilizované MeSH
- indikátory a reagencie MeSH
- kinetika MeSH
- mozek enzymologie MeSH
- oximy MeSH
- prasata MeSH
- pyridinové sloučeniny MeSH
- reaktivátory cholinesterasy farmakologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
Reactivation with bis quaternary aldoxime HI-6, chemical formula 1-(2-hydroxyamino-methylpyridinium)-3-(4-carbamoylpyridinium)-2-oxapropane dichloride of immobilized enzyme acetylcholinesterase inhibited by nerve agent type "G" was studied. This aldoxime is effective in reactivation of sarin-inhibited acetylcholinesterase. Substantially lower reactivation potency was observed with cyclosarin-inhibited enzyme and almost no effect was found for that acetylcholinesterase is the enzyme complex. HI 6 is completely ineffective towards the soman-inhibited enzyme: After a 2-minute inhibition of the enzyme with soman no ability to define reactivator the inhibited enzymes and complexes.
- 000
- 02290naa 2200397 a 4500
- 001
- bmc11020695
- 003
- CZ-PrNML
- 005
- 20130617112944.0
- 008
- 110629s2009 xxu e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Hoskovcová, Monika $7 xx0128579
- 245 10
- $a Study of efficacy of reactivator HI 6 in reactivation of immobilized acetylcholinesterase, inhibited by organophosphorus chemical warfare agents of the "G" series / $c M. Hoskovcová, E. Halámek, Z. Kobliha
- 314 __
- $a University of Defence, Brno, Institute of NBC Defence, Vita Nejedleho, 682 03 Vyskov, Czech Republic. monika.hoskovcova@unob.cz
- 520 9_
- $a Reactivation with bis quaternary aldoxime HI-6, chemical formula 1-(2-hydroxyamino-methylpyridinium)-3-(4-carbamoylpyridinium)-2-oxapropane dichloride of immobilized enzyme acetylcholinesterase inhibited by nerve agent type "G" was studied. This aldoxime is effective in reactivation of sarin-inhibited acetylcholinesterase. Substantially lower reactivation potency was observed with cyclosarin-inhibited enzyme and almost no effect was found for that acetylcholinesterase is the enzyme complex. HI 6 is completely ineffective towards the soman-inhibited enzyme: After a 2-minute inhibition of the enzyme with soman no ability to define reactivator the inhibited enzymes and complexes.
- 590 __
- $a bohemika - dle Pubmed
- 650 _2
- $a acetylcholinesterasa $x metabolismus $7 D000110
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a biosenzitivní techniky $7 D015374
- 650 _2
- $a mozek $x enzymologie $7 D001921
- 650 _2
- $a chemické bojové látky $x farmakologie $7 D002619
- 650 _2
- $a cholinesterasové inhibitory $x farmakologie $7 D002800
- 650 _2
- $a reaktivátory cholinesterasy $x farmakologie $7 D002801
- 650 _2
- $a enzymy imobilizované $7 D004800
- 650 _2
- $a indikátory a reagencie $7 D007202
- 650 _2
- $a kinetika $7 D007700
- 650 _2
- $a chemické modely $7 D008956
- 650 _2
- $a oximy $7 D010091
- 650 _2
- $a pyridinové sloučeniny $7 D011726
- 650 _2
- $a prasata $7 D013552
- 700 1_
- $a Halámek, Emil $7 xx0001011
- 700 1#
- $a Kobliha, Zbyněk. $7 _AN043412
- 773 0_
- $t Drug Metabolism Letters $w MED00174154 $g Roč. 3, č. 1 (2009), s. 54-57 $x 1872-3128
- 910 __
- $a ABA008 $b x $y 2
- 990 __
- $a 20110721122505 $b ABA008
- 991 __
- $a 20130617113332 $b ABA008
- 999 __
- $a ok $b bmc $g 864222 $s 727083
- BAS __
- $a 3
- BMC __
- $a 2009 $x MED00174154 $b 3 $c 1 $d 54-57 $i 1872-3128 $m Drug metabolism letters $n Drug Metab Lett
- LZP __
- $a 2011-3B09/BBjvme
