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Methods for detection of circulating tumour cells and their clinical value in cancer patients
Mikulová V, Kološtová K, Zima T.
Language English Country Czech Republic
Document type Research Support, Non-U.S. Gov't, Review
Grant support
NS9976
MZ0
CEP Register
Digital library NLK
Full text - Article
Source
NLK
Free Medical Journals
from 2000
Freely Accessible Science Journals
from 2000
ProQuest Central
from 2005-01-01
Health & Medicine (ProQuest)
from 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
from 2000
- MeSH
- Immunohistochemistry MeSH
- Immunomagnetic Separation MeSH
- Humans MeSH
- Neoplastic Cells, Circulating metabolism pathology MeSH
- Neoplasms metabolism pathology MeSH
- Reverse Transcriptase Polymerase Chain Reaction MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Currently available analytical methods enable identification, detection and characterization of circulating tumour cells in the peripheral blood and disseminated tumour cells in the bone marrow of breast cancer patients. About 0.01 % of the circulating tumour cells observed in the blood are able to form metastases. Therefore, they could be used for estimation of the risk for metastatic relapse, as a diagnostic tool for patient stratification, early determination of the therapy failure, or potential risk of resistance to the given therapeutic intervention. New therapeutic molecular targets could be identified for management of cancer patients using circulating tumour cell detection. The following review summarizes introduced methods of circulating tumour cell detection and their possible application in clinics.
Obsahuje 2 tabulky
Bibliography, etc.Literatura
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- $a Mikulová, Veronika $7 xx0208972 $u Laboratory of Clinical Immunology and Allergology, Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague
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- $a Methods for detection of circulating tumour cells and their clinical value in cancer patients / $c Mikulová V, Kološtová K, Zima T.
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- $a Currently available analytical methods enable identification, detection and characterization of circulating tumour cells in the peripheral blood and disseminated tumour cells in the bone marrow of breast cancer patients. About 0.01 % of the circulating tumour cells observed in the blood are able to form metastases. Therefore, they could be used for estimation of the risk for metastatic relapse, as a diagnostic tool for patient stratification, early determination of the therapy failure, or potential risk of resistance to the given therapeutic intervention. New therapeutic molecular targets could be identified for management of cancer patients using circulating tumour cell detection. The following review summarizes introduced methods of circulating tumour cell detection and their possible application in clinics.
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- $a Zima, Tomáš, $d 1966- $7 jn20000620440 $u Laboratory of Clinical Immunology and Allergology, Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague
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- $t Folia biologica $x 0015-5500 $g Roč. 57, č. 4 (2011), s. 151-161 $w MED00011004
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