Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Neurogenic pulmonary edema induced by spinal cord injury in spontaneously hypertensive and Dahl salt hypertensive rats

J. Šedý, J. Kuneš, J. Zicha

. 2011 ; 60 (6) : 975-979.

Language English Country Czech Republic

Document type Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc12006383

Neurogenic pulmonary edema (NPE), which is induced by acute spinal cord compression (SCC) under the mild (1.5 %) isoflurane anesthesia, is highly dependent on baroreflex-mediated bradycardia because a deeper (3 %) isoflurane anesthesia or atropine pretreatment completely abolished bradycardia occurrence and NPE development in rats subjected to SCC. The aim of the present study was to evaluate whether hypertensionassociated impairment of baroreflex sensitivity might exert some protection against NPE development in hypertensive animals. We therefore studied SCC-induced NPE development in two forms of experimental hypertension – spontaneously hypertensive rats (SHR) and salt hypertensive Dahl rats, which were reported to have reduced baroreflex sensitivity. SCC elicited NPE in both hypertensive models irrespective of their baroreflex sensitivity. It is evident that a moderate impairment of baroreflex sensitivity, which was demonstrated in salt hypertensive Dahl rats, does not exert sufficient protective effects against NPE development.

References provided by Crossref.org

Obsahuje 2 tabulky

Bibliography, etc.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc12006383
003      
CZ-PrNML
005      
20121002061046.0
007      
ta
008      
120229s2011 xr f 000 0eng||
009      
AR
024    7_
$a 10.33549/physiolres.932281 $2 doi
040    __
$a ABA008 $d ABA008 $e AACR2 $b cze
041    0_
$a eng
044    __
$a xr
100    1_
$a Šedý, Jiří, $d 1980- $7 mzk2007411473 $u Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
245    10
$a Neurogenic pulmonary edema induced by spinal cord injury in spontaneously hypertensive and Dahl salt hypertensive rats / $c J. Šedý, J. Kuneš, J. Zicha
500    __
$a Obsahuje 2 tabulky
504    __
$a Literatura $b 18
520    9_
$a Neurogenic pulmonary edema (NPE), which is induced by acute spinal cord compression (SCC) under the mild (1.5 %) isoflurane anesthesia, is highly dependent on baroreflex-mediated bradycardia because a deeper (3 %) isoflurane anesthesia or atropine pretreatment completely abolished bradycardia occurrence and NPE development in rats subjected to SCC. The aim of the present study was to evaluate whether hypertensionassociated impairment of baroreflex sensitivity might exert some protection against NPE development in hypertensive animals. We therefore studied SCC-induced NPE development in two forms of experimental hypertension – spontaneously hypertensive rats (SHR) and salt hypertensive Dahl rats, which were reported to have reduced baroreflex sensitivity. SCC elicited NPE in both hypertensive models irrespective of their baroreflex sensitivity. It is evident that a moderate impairment of baroreflex sensitivity, which was demonstrated in salt hypertensive Dahl rats, does not exert sufficient protective effects against NPE development.
650    _2
$a zvířata $7 D000818
650    _2
$a baroreflex $7 D017704
650    _2
$a krevní tlak $7 D001794
650    _2
$a hypertenze $x komplikace $x patofyziologie $7 D006973
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a neurony $x metabolismus $7 D009474
650    _2
$a plicní edém $x etiologie $x patofyziologie $x prevence a kontrola $7 D011654
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a potkani inbrední Dahl $7 D020303
650    _2
$a komprese míchy $x komplikace $x patologie $7 D013117
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Kuneš, Jaroslav, $d 1948- $7 nlk19990073450 $u Institute of Physiology, Academy of Sciences of the Czech Republic, Prague; Cardiovascular Research Center, Prague
700    1_
$a Zicha, Josef, $d 1950- $7 jk01152609 $u Institute of Physiology, Academy of Sciences of the Czech Republic, Prague; Cardiovascular Research Center, Prague
773    0_
$t Physiological research $x 0862-8408 $g Roč. 60, č. 6 (2011), s. 975-979 $w MED00003824
910    __
$a ABA008 $b A 4120 $c 266 $y 2
990    __
$a 20120229072848 $b ABA008
991    __
$a 20121002061236 $b ABA008
999    __
$a ok $b bmc $g 899436 $s 763212
BAS    __
$a 3
BMC    __
$a 2011 $b 60 $c 6 $d 975-979 $i 0862-8408 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$a 2012-12/ipme
Back

Find record

Citation metrics

Archiving options