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Synthesis of fluorescent C24-ceramide: evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin
J Novotny, K Pospechova, A Hrabalek, R Cap, K Vavrova
Bioorganic & medicinal chemistry letters.
2009 ;
19 (24) :
6975-6977.
Language English Country Great Britain
Document type Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/bmc12008474
Online
NLK
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- 4-Chloro-7-nitrobenzofurazan chemical synthesis metabolism MeSH
- Dermatitis, Atopic metabolism MeSH
- Bisbenzimidazole metabolism MeSH
- Ceramides chemical synthesis metabolism MeSH
- Fluorescence MeSH
- Fluorescent Dyes chemical synthesis metabolism MeSH
- Skin metabolism MeSH
- Humans MeSH
- Permeability MeSH
- Psoriasis metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Topical skin lipid supplementation may provide opportunities for controlling ceramide (Cer) deficiency in skin diseases such as atopic dermatitis or psoriasis. Here we describe the synthesis of a long-chain 7-nitrobenzo[c][1,2,5]oxadiazol-4-yl (NBD)-labeled Cer and its different penetration through human skin compared to widely used short-chain fluorescent Cer tools.
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