Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Presentation, management and outcome of 32 patients with pregnancy-associated breast cancer: a matched controlled study

M. J. Halaska, G. Pentheroudakis, P. Strnad, H. Stankusova, J. Chod, H. Robova, L. Petruzelka, L. Rob, N. Pavlidis

. 2009 ; 15 (5) : 461-467.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu práce podpořená grantem, multicentrická studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc12008498

Grantová podpora
NR9455 MZ0 CEP - Centrální evidence projektů

Pregnancy-associated breast cancer (PABC) is a rare and challenging problem. We sought to describe epidemiology, management and outcome of women in whom breast cancer was diagnosed during pregnancy or within one year after delivery. Thirty-two women with PABC were referred to two European Union oncology centers between 1995 and 2007, 16 during pregnancy and 16 within 1 year after delivery. Data concerning diagnosis, management, delivery and fetal and maternal outcome were recorded. A group of 32 patients (matched controls) presenting with nonpregnancy-associated breast cancer (non-PABC) was matched for age at diagnosis, tumor size and stage to each PABC patient. Differences in outcome between the PABC and non-PABC groups were then assessed. Histological features were similar in both groups, except that estrogen receptor-negative tumors were more common in the PABC group. Three patients received chemotherapy and two others underwent surgery during pregnancy, with no excess toxicity or severe maternal/fetal adverse effects. All children in the PABC group were healthy, except for one exposed to epirubicin in utero and born with rectal atresia. Overall survival was similar in PABC and non-PABC patients (p = 0.449). The subgroup of patients with breast cancer diagnosed within one year after delivery showed a shorter time to relapse than controls or patients with gestational cancer (p = 0.0178). PABC is a special situation, necessitating individualized, multi-disciplinary management. Prognosis is similar for women with nongestational cancer matched for age and stage though poorer outcome postpartum should be further investigated.

Citace poskytuje Crossref.org

000      
04118naa a2200637 a 4500
001      
bmc12008498
003      
CZ-PrNML
005      
20140711141640.0
008      
120316s2009 xxu eng||
009      
AR
024    __
$a 10.1111/j.1524-4741.2009.00760.x $2 doi
035    __
$a (PubMed)19624421
040    __
$a ABA008 $b cze $d ABA008
041    0_
$a eng
044    __
$a xxu
100    1_
$a Halaška, Michael J., $d 1975- $7 xx0062494 $u Department of Obstetrics and Gynecology, Second Medical Faculty, Charles University in Prague, Prague, Czech Republic. mhalaska@centrum.cz
245    10
$a Presentation, management and outcome of 32 patients with pregnancy-associated breast cancer: a matched controlled study / $c M. J. Halaska, G. Pentheroudakis, P. Strnad, H. Stankusova, J. Chod, H. Robova, L. Petruzelka, L. Rob, N. Pavlidis
520    9_
$a Pregnancy-associated breast cancer (PABC) is a rare and challenging problem. We sought to describe epidemiology, management and outcome of women in whom breast cancer was diagnosed during pregnancy or within one year after delivery. Thirty-two women with PABC were referred to two European Union oncology centers between 1995 and 2007, 16 during pregnancy and 16 within 1 year after delivery. Data concerning diagnosis, management, delivery and fetal and maternal outcome were recorded. A group of 32 patients (matched controls) presenting with nonpregnancy-associated breast cancer (non-PABC) was matched for age at diagnosis, tumor size and stage to each PABC patient. Differences in outcome between the PABC and non-PABC groups were then assessed. Histological features were similar in both groups, except that estrogen receptor-negative tumors were more common in the PABC group. Three patients received chemotherapy and two others underwent surgery during pregnancy, with no excess toxicity or severe maternal/fetal adverse effects. All children in the PABC group were healthy, except for one exposed to epirubicin in utero and born with rectal atresia. Overall survival was similar in PABC and non-PABC patients (p = 0.449). The subgroup of patients with breast cancer diagnosed within one year after delivery showed a shorter time to relapse than controls or patients with gestational cancer (p = 0.0178). PABC is a special situation, necessitating individualized, multi-disciplinary management. Prognosis is similar for women with nongestational cancer matched for age and stage though poorer outcome postpartum should be further investigated.
590    __
$a bohemika - dle Pubmed
650    02
$a indukovaný potrat $x statistika a číselné údaje $7 D000028
650    02
$a protinádorové látky $x terapeutické užití $7 D000970
650    02
$a nádory prsu $x diagnóza $x mortalita $x patologie $x terapie $7 D001943
650    02
$a císařský řez $7 D002585
650    02
$a kombinovaná terapie $7 D003131
650    02
$a vedení porodu $7 D036861
650    02
$a ženské pohlaví $7 D005260
650    02
$a lidé $7 D006801
650    02
$a těhotenství $7 D011247
650    02
$a nádorové komplikace v těhotenství $x diagnóza $x chirurgie $x mortalita $x terapie $7 D011252
650    02
$a poruchy v puerperiu $x diagnóza $x mortalita $x patologie $x terapie $7 D011644
650    02
$a radioterapie $7 D011878
650    02
$a receptor erbB-2 $x analýza $7 D018719
650    02
$a receptory pro estrogeny $x analýza $7 D011960
650    02
$a receptory progesteronu $x analýza $7 D011980
650    02
$a retrospektivní studie $7 D012189
650    02
$a výsledek terapie $7 D016896
651    _2
$a Česká republika $7 D018153
651    _2
$a Řecko $7 D006115
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a multicentrická studie $7 D016448
700    1_
$a Pentheroudakis, George $u Department of Medical Oncology, Ioannina University Hospital, Ioannina, Greece
700    1_
$a Strnad, Pavel, $d 1951- $7 jn20011210213 $u Department of Obstetrics and Gynecology, Second Medical Faculty, Charles University in Prague, Prague, Czech Republic
700    1_
$a Stankušová, Hana $7 xx0084176 $u Department of Radiation and Oncology, FN Motol, Prague, Czech Republic
700    1_
$a Chod, Jiří, $d 1969- $7 xx0083029 $u Department of Obstetrics and Gynecology, Second Medical Faculty, Charles University in Prague, Prague, Czech Republic
700    1_
$a Robová, Helena $7 xx0110282 $u Department of Obstetrics and Gynecology, Second Medical Faculty, Charles University in Prague, Prague, Czech Republic
700    1_
$a Petruželka, Luboš, $d 1952- $7 jn19990209650 $u Department of Oncology, First Medical Faculty, Charles University in Prague, Prague, Czech Republic
700    1_
$a Rob, Lukáš, $d 1958- $7 xx0017807 $u Department of Obstetrics and Gynecology, Second Medical Faculty, Charles University in Prague, Prague, Czech Republic
700    1_
$a Pavlidis, Nicholas $u Department of Medical Oncology, Ioannina University Hospital, Ioannina, Greece
773    0_
$t The breast journal $p Breast J $g Roč. 15, č. 5 (2009), s. 461-467 $w MED00007145 $x 1075-122X
910    __
$a ABA008 $b x $y 4 $z 0
990    __
$a 20120319124450 $b ABA008
991    __
$a 20140711141934 $b ABA008
999    __
$a ok $b bmc $g 901877 $s 765393
BAS    __
$a 3
BMC    __
$a 2009 $b 15 $c 5 $d 461-467 $m The breast journal $x MED00007145 $i 1075-122X $n Breast J
GRA    __
$a NR9455 $p MZ0
LZP    __
$a 2012-1Q10/jt

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace