Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Comparison of the effects of ketamine-dexmedetomidine and sevoflurane-sufentanil anesthesia on cardiac biomarkers after cardiac surgery: an observational study

H. Říha, T. Kotulák, A. Březina, L. Hess, P. Kramář, O. Szárszoi, I. Netuka, J. Pirk

. 2012 ; 61 (1) : 63-72.

Jazyk angličtina Země Česko

Typ dokumentu srovnávací studie, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc12012543

Inhalational anesthetics have demonstrated cardioprotective effects against myocardial ischemia-reperfusion injury. Clinical studies in cardiac surgery have supported these findings, although not with the consistency demonstrated in experimental studies. Recent investigations have questioned the advantages of inhalational over intravenous anesthetics with respect to cardiac protection. Ketamine has been shown to be comparable with sufentanil, and has even demonstrated anti-inflammatory properties. Dexmedetomidine has been established as a sedative/anesthetic drug with analgesic properties, and has also demonstrated myocardial protective effects. In this retrospective observational study, the influence of ketamine-dexmedetomidinebased anesthesia (KET-DEX group; n=17) on the release of cardiac biomarkers was compared with that of sevofluranesufentanil- based anesthesia (SEVO group; n=21) in patients undergoing elective coronary artery bypass grafting. Compared with the SEVO group, the KET-DEX group exhibited significantly reduced cardiac troponin I (2.22±1.73 vs. 3.63±2.37 μg/l; P=0.02) and myocardial fraction of creatine kinase (CK-MB) levels (12.4±10.4 vs. 20.3±11.2 μg/l; P=0.01) on the morning of the first postoperative day. Furthermore, cardiac troponin I release, evaluated as the area under the curve, was significantly reduced in the KET-DEX group (32.1±20.1 vs. 50.6±23.2; P=0.01). These results demonstrate the cardioprotective effects of ketamine-dexmedetomidine anesthesia compared with those of sevoflurane-sufentanil anesthesia.

Citace poskytuje Crossref.org

Obsahuje 3 tabulky

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc12012543
003      
CZ-PrNML
005      
20140414124510.0
007      
ta
008      
120413s2012 xr d f 000 0eng||
009      
AR
024    7_
$a 10.33549/physiolres.932224 $2 doi
035    __
$a (PubMed)22188112
040    __
$a ABA008 $d ABA008 $e AACR2 $b cze
041    0_
$a eng
044    __
$a xr
100    1_
$a Říha, Hynek. $7 xx0185812 $u Department of Anesthesiology and Intensive Care Medicine, Institute for Clinical and Experimental Medicine, Prague; Centre for Cardiovascular Research, Prague
245    10
$a Comparison of the effects of ketamine-dexmedetomidine and sevoflurane-sufentanil anesthesia on cardiac biomarkers after cardiac surgery: an observational study / $c H. Říha, T. Kotulák, A. Březina, L. Hess, P. Kramář, O. Szárszoi, I. Netuka, J. Pirk
500    __
$a Obsahuje 3 tabulky
504    __
$a Literatura $b 31
520    3_
$a Inhalational anesthetics have demonstrated cardioprotective effects against myocardial ischemia-reperfusion injury. Clinical studies in cardiac surgery have supported these findings, although not with the consistency demonstrated in experimental studies. Recent investigations have questioned the advantages of inhalational over intravenous anesthetics with respect to cardiac protection. Ketamine has been shown to be comparable with sufentanil, and has even demonstrated anti-inflammatory properties. Dexmedetomidine has been established as a sedative/anesthetic drug with analgesic properties, and has also demonstrated myocardial protective effects. In this retrospective observational study, the influence of ketamine-dexmedetomidinebased anesthesia (KET-DEX group; n=17) on the release of cardiac biomarkers was compared with that of sevofluranesufentanil- based anesthesia (SEVO group; n=21) in patients undergoing elective coronary artery bypass grafting. Compared with the SEVO group, the KET-DEX group exhibited significantly reduced cardiac troponin I (2.22±1.73 vs. 3.63±2.37 μg/l; P=0.02) and myocardial fraction of creatine kinase (CK-MB) levels (12.4±10.4 vs. 20.3±11.2 μg/l; P=0.01) on the morning of the first postoperative day. Furthermore, cardiac troponin I release, evaluated as the area under the curve, was significantly reduced in the KET-DEX group (32.1±20.1 vs. 50.6±23.2; P=0.01). These results demonstrate the cardioprotective effects of ketamine-dexmedetomidine anesthesia compared with those of sevoflurane-sufentanil anesthesia.
650    02
$a senioři $7 D000368
650    02
$a kombinace anestetik $7 D019162
650    02
$a anestetika inhalační $7 D018685
650    02
$a biologické markery $x krev $7 D015415
650    02
$a kardiotonika $x farmakologie $7 D002316
650    02
$a dexmedetomidin $7 D020927
650    02
$a ženské pohlaví $7 D005260
650    02
$a lidé $7 D006801
650    02
$a ketamin $7 D007649
650    02
$a mužské pohlaví $7 D008297
650    02
$a methylethery $7 D008738
650    02
$a lidé středního věku $7 D008875
650    02
$a retrospektivní studie $7 D012189
650    02
$a sufentanil $7 D017409
650    02
$a hrudní chirurgie $7 D013903
655    _2
$a srovnávací studie $7 D003160
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Kotulák, Tomáš $7 xx0108024 $u Department of Anesthesiology and Intensive Care Medicine, Institute for Clinical and Experimental Medicine, Prague
700    1_
$a Březina, Aleš, $d 1952- $7 jn20000400348 $u Department of Anesthesiology and Intensive Care Medicine, Institute for Clinical and Experimental Medicine, Prague
700    1_
$a Hess, Ladislav, $d 1948- $7 nlk20030145275 $u Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague
700    1_
$a Kramář, Petr. $7 xx0276971 $u Department of Anesthesiology and Intensive Care Medicine, Institute for Clinical and Experimental Medicine, Prague
700    1_
$a Szárszoi, Ondrej, $d 1974- $7 xx0036687 $u Centre for Cardiovascular Research, Prague; Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague
700    1_
$a Netuka, Ivan, $d 1973- $7 xx0074183 $u Centre for Cardiovascular Research, Prague; Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague
700    1_
$a Pirk, Jan, $d 1948- $7 nlk19990073700 $u Centre for Cardiovascular Research, Prague; Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague
773    0_
$t Physiological research $x 0862-8408 $g Roč. 61, č. 1 (2012), s. 63-72 $w MED00003824
856    41
$u http://www.biomed.cas.cz/physiolres/archive.htm
910    __
$a ABA008 $b A 4120 $c 266 $y 4 $z 0
990    __
$a 20120412105928 $b ABA008
991    __
$a 20140414124604 $b ABA008
999    __
$a ok $b bmc $g 905984 $s 769530
BAS    __
$a 3
BMC    __
$a 2012 $b 61 $c 1 $d 63-72 $i 0862-8408 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$a 2012-22/ipme

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace