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Post-systolic shortening influences early diastolic filling in patients with dilated cardiomyopathy
Helena Podroužková, Jaroslav Meluzín, Petr Hude, Jan Krejčí, Lenka Špinarová, Jíří Vítovec
Jazyk angličtina Země Česko
- Klíčová slova
- diastolic function,
- MeSH
- diastola MeSH
- dilatační kardiomyopatie komplikace patofyziologie MeSH
- echokardiografie metody MeSH
- elektrokardiografie metody MeSH
- experimenty na lidech MeSH
- financování organizované MeSH
- funkce levé komory srdeční fyziologie MeSH
- klinické laboratorní techniky MeSH
- kontrakce myokardu fyziologie MeSH
- lidé MeSH
- rentgendiagnostika hrudníku MeSH
- retrospektivní studie MeSH
- srdeční selhání etiologie patofyziologie MeSH
- statistika jako téma MeSH
- systola MeSH
- Check Tag
- lidé MeSH
Background We investigated whether post-systolic contraction has an impact on the diastolic function in patients with dilated cardiomyopathy (DCM). Methods Forty-eight DCM patients and 14 healthy volunteers underwent standard echocardiography, tissue Doppler imaging and strain focusing on diastolic function. The loops were recorded and post-systolic strain index (PSI) derived from speckle tracking strain analysis was assessed off-line. Results The post-systolic contraction was observed in 86% of the DCM patients. In correlations of post-systolic strain index and individual diastolic parameters, mitral anulus velocity in early diastole (Ea) showed statistically significant relation (r=−0.48, p=0.001) as well as the ratio of peak velocity of transmitral filling in early diastole and mitral anulus velocity in early diastole (E/Ea) (r=0.39, p=0.012). Other assessed diastolic parameters did not reveal any significant correlations with PSI; peak velocity of transmitral filling in early (E) and late diastole (A), decelerating time of early diastolic filling (DT), mitral anulus velocity in late diastole (Aa). Conclusion There is a significant association between post-systolic shortening and a worsening of left ventricle (LV) diastolic filling in DCM patients.
Obsahuje 3 tabulky
Bibliografie atd.Literatura
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- $a Background We investigated whether post-systolic contraction has an impact on the diastolic function in patients with dilated cardiomyopathy (DCM). Methods Forty-eight DCM patients and 14 healthy volunteers underwent standard echocardiography, tissue Doppler imaging and strain focusing on diastolic function. The loops were recorded and post-systolic strain index (PSI) derived from speckle tracking strain analysis was assessed off-line. Results The post-systolic contraction was observed in 86% of the DCM patients. In correlations of post-systolic strain index and individual diastolic parameters, mitral anulus velocity in early diastole (Ea) showed statistically significant relation (r=−0.48, p=0.001) as well as the ratio of peak velocity of transmitral filling in early diastole and mitral anulus velocity in early diastole (E/Ea) (r=0.39, p=0.012). Other assessed diastolic parameters did not reveal any significant correlations with PSI; peak velocity of transmitral filling in early (E) and late diastole (A), decelerating time of early diastolic filling (DT), mitral anulus velocity in late diastole (Aa). Conclusion There is a significant association between post-systolic shortening and a worsening of left ventricle (LV) diastolic filling in DCM patients.
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