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Expression and characterization of c-Myb in prenatal odontogenesis
E. Matalová, M. Buchtová, AS. Tucker, TP. Bender, E. Janečková, V. Lungová, S. Balková, J. Smarda
Language English Country Japan
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
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from 1969 to 1 year ago
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- MeSH
- Alleles MeSH
- Ameloblasts cytology metabolism MeSH
- Apoptosis MeSH
- Dentition MeSH
- Species Specificity MeSH
- Embryo, Mammalian cytology embryology metabolism MeSH
- Immunohistochemistry MeSH
- Cloning, Molecular MeSH
- In Situ Nick-End Labeling MeSH
- Swine, Miniature MeSH
- Mice MeSH
- Odontoblasts cytology metabolism MeSH
- Odontogenesis MeSH
- Osteoclasts cytology metabolism MeSH
- Swine MeSH
- Cell Proliferation MeSH
- Proliferating Cell Nuclear Antigen metabolism MeSH
- Cell Cycle Proteins genetics metabolism MeSH
- Proto-Oncogene Proteins c-myb genetics metabolism MeSH
- Trans-Activators genetics metabolism MeSH
- Gene Expression Regulation, Developmental MeSH
- Tooth cytology embryology metabolism MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odontogenesis. In the minipig, in contrast to the mouse, there was an asymmetrical arrangement of c-Myb positive cells, with a higher presence on the labial side of the tooth germ and dental lamina. A cluster of negative cells was situated in the mesenchyme close to the tooth bud. At later stages, the number of positive cells decreased and these cells were situated in the upper part of the dental papilla in the areas of future cusp formation. The expression of c-Myb in both species was strong in the odontoblasts and ameloblasts at the stage of dentin and enamel production suggesting a possible novel role of c-Myb during tooth mineralization.
Department of Craniofacial Development and Orthodontics KCL London UK
Department of Experimental Biology Faculty of Science Masaryk University Brno Czech Republic
Department of Microbiology University of Virginia Charlottesville Virginia USA
Faculty of Veterinary Medicine University of Veterinary and Pharmaceutical Sciences Brno Czech Re
References provided by Crossref.org
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