• Je něco špatně v tomto záznamu ?

Sublingual isosorbide dinitrate for the detection of obstruction in hypertrophic cardiomyopathy

D. Zemánek, P. Tomasov, S. Homolová, K. Linhartová, J. Veselka

. 2011 ; 12 (9) : 684-687. [pub] 20110804

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc12022259

AIMS: Hypertrophic cardiomyopathy (HCM) is predominantly associated with left ventricular outflow tract (LVOT) obstruction. The assessment of the obstruction with a provoking test should be a routine part of HCM evaluation. The aim of the study was to determine the utility of a sublingual spray application of isosorbide dinitrate (ISDN) for detection of an obstruction. METHODS AND RESULTS: We have prospectively analysed 77 consecutive HCM patients, measuring the LVOT gradient at rest, using the sublingual spray application of ISDN (2.5 mg; after 2, 5, and 10 min), and with exercise echocardiography. An obstruction was defined as a gradient ≥ 30 mmHg. An obstruction was present in 15 patients (19%) at rest, in 42 patients (55%) after ISDN, and in 55 patients (71%) after exercise. The ISDN test had a sensitivity of 76% and the specificity of 100% relative to exercise echocardiography, while at-rest measurements had a sensitivity of 27% and a specificity of 100%. The chronological difference in the prevalence of obstructions during the ISDN test was statistically significant (P < 0.05); at ISDN plus 2 min, obstructions were seen in only 29 patients (38%, gradient 28.8 ± 25.0 mmHg), however, at ISDN plus 5 and 10 min, obstructions were found in 42 patients (55%, gradient 44.5 ± 39.6 mmHg). CONCLUSION: The ISDN test is a reliable screening method for the detection of an HCM obstruction, however, the measurement should be delayed 5-10 min after the application of ISDN. Patients with negative ISDN tests should undergo exercise echocardiography.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12022259
003      
CZ-PrNML
005      
20160323105205.0
007      
ta
008      
120806s2011 xxk f 000 0#eng||
009      
AR
024    7_
$a 10.1093/ejechocard/jer115 $2 doi
035    __
$a (PubMed)21821607
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Zemánek, David, $d 1972- $7 xx0079099 $u Department of Cardiology, University Hospital Motol, First and Second Medical School of Charles University, V Uvalu 84, 150 21 Prague, Czech Republic
245    10
$a Sublingual isosorbide dinitrate for the detection of obstruction in hypertrophic cardiomyopathy / $c D. Zemánek, P. Tomasov, S. Homolová, K. Linhartová, J. Veselka
520    9_
$a AIMS: Hypertrophic cardiomyopathy (HCM) is predominantly associated with left ventricular outflow tract (LVOT) obstruction. The assessment of the obstruction with a provoking test should be a routine part of HCM evaluation. The aim of the study was to determine the utility of a sublingual spray application of isosorbide dinitrate (ISDN) for detection of an obstruction. METHODS AND RESULTS: We have prospectively analysed 77 consecutive HCM patients, measuring the LVOT gradient at rest, using the sublingual spray application of ISDN (2.5 mg; after 2, 5, and 10 min), and with exercise echocardiography. An obstruction was defined as a gradient ≥ 30 mmHg. An obstruction was present in 15 patients (19%) at rest, in 42 patients (55%) after ISDN, and in 55 patients (71%) after exercise. The ISDN test had a sensitivity of 76% and the specificity of 100% relative to exercise echocardiography, while at-rest measurements had a sensitivity of 27% and a specificity of 100%. The chronological difference in the prevalence of obstructions during the ISDN test was statistically significant (P < 0.05); at ISDN plus 2 min, obstructions were seen in only 29 patients (38%, gradient 28.8 ± 25.0 mmHg), however, at ISDN plus 5 and 10 min, obstructions were found in 42 patients (55%, gradient 44.5 ± 39.6 mmHg). CONCLUSION: The ISDN test is a reliable screening method for the detection of an HCM obstruction, however, the measurement should be delayed 5-10 min after the application of ISDN. Patients with negative ISDN tests should undergo exercise echocardiography.
650    _2
$a aplikace sublinguální $7 D000286
650    _2
$a hypertrofická kardiomyopatie $x patofyziologie $7 D002312
650    _2
$a zátěžová echokardiografie $7 D025401
650    _2
$a zátěžový test $7 D005080
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a isosorbiddinitrát $x aplikace a dávkování $x diagnostické užití $7 D007548
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a senzitivita a specificita $7 D012680
650    _2
$a vazodilatancia $x aplikace a dávkování $x diagnostické užití $7 D014665
650    _2
$a obstrukce výtoku ze srdeční komory $x komplikace $x ultrasonografie $7 D014694
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Tomašov, Pavol, $d 1982- $7 xx0243010 $u Department of Cardiology, University Hospital Motol and Second Medical School of Charles University, Prague, Czech Republic
700    1_
$a Homolová, Stanislava $7 _AN033515 $u Department of Cardiology, University Hospital Motol and Second Medical School of Charles University, Prague, Czech Republic
700    1_
$a Linhartová, Kateřina, $d 1964- $7 xx0063473 $u Department of Cardiology, University Hospital Motol, First and Second Medical School of Charles University, V Uvalu 84, 150 21 Prague, Czech Republic
700    1_
$a Veselka, Josef, $d 1965- $7 pna2005261820 $u Department of Cardiology, University Hospital Motol, First and Second Medical School of Charles University, V Uvalu 84, 150 21 Prague, Czech Republic
773    0_
$w MED00006445 $t European journal of echocardiography the journal of the Working Group on Echocardiography of the European Society of Cardiology $x 1532-2114 $g Roč. 12, č. 9 (2011), s. 684-687
856    41
$u https://pubmed.ncbi.nlm.nih.gov/21821607 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m $z 0
990    __
$a 20120806 $b ABA008
991    __
$a 20160323105232 $b ABA008
999    __
$a ok $b bmc $g 944172 $s 779556
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2011 $b 12 $c 9 $d 684-687 $e 20110804 $i 1532-2114 $m European journal of echocardiography $n Eur J Echocardiogr $x MED00006445
LZP    __
$b NLK111 $a Pubmed-20120806/12/01

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...