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Synthesis and antiviral evaluation of the 2′-C-methyl branched derivative of a nucleoside analog inhibitor of RNA viral infections, T-1106

Claire Pierra, Clément Counor, Richard Storer and Gilles Gosselin

. 2011 ; 76 (11) : 1327-1333.

Language English Country Czech Republic Media elektronický zdroj

Persistent link   https://www.medvik.cz/link/bmc12022658

An example of a 2′-C-methyl branched nucleoside analogue bearing 3,4-dihydro-3-oxopyrazine-2-carboxamide as the base, namely 4-(2-C-methyl-β-D-ribofuranosyl)-3-oxo-3,4-dihydropyrazine-2-carboxamide, is reported. This compound was synthesized following a Vorbrüggen's glycosylation procedure in a few steps. When evaluated in cell culture experiments against a broad range of viruses, this compound did not exhibit any significant antiviral effect or cytotoxicity.

Synthesis and antiviral evaluation of the 2′-C-methyl branched derivative of a nucleoside analog inhibitor of RNA viral infections, T-1106 [elektronický zdroj] /

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