-
Something wrong with this record ?
The impact of the microbial load of genital mycoplasmas and gestational age on the intensity of intraamniotic inflammation
M. Kacerovsky, L. Pliskova, R. Bolehovska, K. Skogstrand, DM. Hougaard, P. Tsiartas, B. Jacobsson,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NS10382
MZ0
CEP Register
- MeSH
- Amniocentesis MeSH
- Bacterial Load MeSH
- Chorioamnionitis diagnosis microbiology MeSH
- DNA, Bacterial analysis MeSH
- Adult MeSH
- Gestational Age MeSH
- Pregnancy Complications, Infectious diagnosis microbiology MeSH
- Humans MeSH
- Inflammation Mediators analysis MeSH
- Young Adult MeSH
- Mycoplasma Infections diagnosis MeSH
- Amniotic Fluid chemistry microbiology MeSH
- Fetal Membranes, Premature Rupture microbiology MeSH
- Prospective Studies MeSH
- Severity of Illness Index MeSH
- Pregnancy MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
OBJECTIVE: The objective of the study was to determine whether the bacterial load of genital mycoplasmas and gestation age are related to intraamniotic inflammatory response using the amniotic fluid levels of 18 inflammatory mediators. STUDY DESIGN: A prospective study of 145 women with singleton pregnancies complicated by preterm prelabor rupture of membranes between 24(0/7) and 36(6/7) weeks was conducted. Amniotic fluid was obtained from all women by transabdominal amniocentesis. The amounts of genital mycoplasma deoxyribonucleic acid were determined using the threshold cycle value and relative and absolute quantification techniques. A panel of multiple proteins was analyzed simultaneously using multiplex technology. RESULTS: Twenty-four women with the presence of genital mycoplasmas in amniotic fluid were included in the final analyses. The concentrations of 9 of the 18 evaluated proteins in the amniotic fluid correlated with bacterial load of genital mycoplasmas independent of the quantification technique used. CONCLUSION: The intensity of intraamniotic inflammatory response to genital mycoplasmas decreased with gestational age.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc12024019
- 003
- CZ-PrNML
- 005
- 20140905133344.0
- 007
- ta
- 008
- 120815e20120112xxu f 000 0#eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.ajog.2012.01.004 $2 doi
- 035 __
- $a (PubMed)22340945
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Kacerovsky, Marian $u Department of Obstetrics and Gynecology, Charles University in Prague, Prague, Czech Republic. kacermar@fnhk.cz
- 245 14
- $a The impact of the microbial load of genital mycoplasmas and gestational age on the intensity of intraamniotic inflammation / $c M. Kacerovsky, L. Pliskova, R. Bolehovska, K. Skogstrand, DM. Hougaard, P. Tsiartas, B. Jacobsson,
- 520 9_
- $a OBJECTIVE: The objective of the study was to determine whether the bacterial load of genital mycoplasmas and gestation age are related to intraamniotic inflammatory response using the amniotic fluid levels of 18 inflammatory mediators. STUDY DESIGN: A prospective study of 145 women with singleton pregnancies complicated by preterm prelabor rupture of membranes between 24(0/7) and 36(6/7) weeks was conducted. Amniotic fluid was obtained from all women by transabdominal amniocentesis. The amounts of genital mycoplasma deoxyribonucleic acid were determined using the threshold cycle value and relative and absolute quantification techniques. A panel of multiple proteins was analyzed simultaneously using multiplex technology. RESULTS: Twenty-four women with the presence of genital mycoplasmas in amniotic fluid were included in the final analyses. The concentrations of 9 of the 18 evaluated proteins in the amniotic fluid correlated with bacterial load of genital mycoplasmas independent of the quantification technique used. CONCLUSION: The intensity of intraamniotic inflammatory response to genital mycoplasmas decreased with gestational age.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a amniocentéza $7 D000649
- 650 _2
- $a plodová voda $x chemie $x mikrobiologie $7 D000653
- 650 _2
- $a bakteriální nálož $7 D058491
- 650 _2
- $a chorioamnionitida $x diagnóza $x mikrobiologie $7 D002821
- 650 _2
- $a DNA bakterií $x analýza $7 D004269
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a předčasný odtok plodové vody $x mikrobiologie $7 D005322
- 650 _2
- $a gestační stáří $7 D005865
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mediátory zánětu $x analýza $7 D018836
- 650 _2
- $a mykoplazmové infekce $x diagnóza $7 D009175
- 650 _2
- $a těhotenství $7 D011247
- 650 _2
- $a infekční komplikace v těhotenství $x diagnóza $x mikrobiologie $7 D011251
- 650 _2
- $a prospektivní studie $7 D011446
- 650 _2
- $a stupeň závažnosti nemoci $7 D012720
- 650 _2
- $a mladý dospělý $7 D055815
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Pliskova, Lenka
- 700 1_
- $a Bolehovska, Radka
- 700 1_
- $a Skogstrand, Kristin
- 700 1_
- $a Hougaard, David M
- 700 1_
- $a Tsiartas, Panagiotis
- 700 1_
- $a Jacobsson, Bo
- 773 0_
- $w MED00000270 $t American journal of obstetrics and gynecology $x 1097-6868 $g Roč. 206, č. 4 (20120112), s. 342.e1-8
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/22340945 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y m $z 0
- 990 __
- $a 20120815 $b ABA008
- 991 __
- $a 20140905133740 $b ABA008
- 999 __
- $a ok $b bmc $g 946167 $s 781347
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2012 $b 206 $c 4 $d 342.e1-8 $e 20120112 $i 1097-6868 $m American journal of obstetrics and gynecology $n Am J Obstet Gynecol $x MED00000270
- GRA __
- $a NS10382 $p MZ0
- LZP __
- $a Pubmed-20120815/12/02
