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Where splicing joins chromatin
J. Hnilicová, D. Staněk,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
NLK
Free Medical Journals
from 2010 to 1 year ago
PubMed Central
from 2010
Europe PubMed Central
from 2010 to 1 year ago
Taylor & Francis Open Access
from 2010-01-01
Medline Complete (EBSCOhost)
from 2011-11-01
- MeSH
- Chromatin genetics metabolism MeSH
- Transcription, Genetic genetics MeSH
- Humans MeSH
- Nucleoproteins metabolism MeSH
- RNA Precursors genetics MeSH
- RNA Splicing MeSH
- Transcription Factors metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
There are numerous data suggesting that two key steps in gene expression-transcription and splicing influence each other closely. For a long time it was known that chromatin modifications regulate transcription, but only recently it was shown that chromatin and histone modifications play a significant role in pre-mRNA splicing. Here we summarize interactions between splicing machinery and chromatin and discuss their potential functional significance. We focus mainly on histone acetylation and methylation and potential mechanisms of their role in splicing. It seems that whereas histone acetylation acts mainly by alterating the transcription rate, histone methylation can also influence splicing directly by recruiting various splicing components.
References provided by Crossref.org
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