• Je něco špatně v tomto záznamu ?

The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years

Ivo Paclt, Ivana Drtílková, Marta Kopečková, Pavel Theiner, Omar Šerý, Nikol Čermáková

. 2010 ; 31 (1) : 131-136.

Jazyk angličtina Země Švédsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc12025197

Grantová podpora
NR9534 MZ0 CEP - Centrální evidence projektů

OBJECTIVE: The purpose of this study was the correlation of the combined type of ADHD in children and Taq IA polymorphism DRD2 gene. We hypothesized a positive correlation of DRD2 polymorphisms in the combined type of ADHD patients without co-morbidity. PATIENTS AND METHODS: Our research sample included 586 unrelated boys of the Czech origin aged between 6 and 13 years. The ADHD group consisted of 269 boys and the control group consisted of 317 boys. PCR detection of the DRD2 polymorphism was carried out by using primers, described by Grandy (Grandy et al. 1989). RESULTS: The comparison of genotype frequencies showed statistically highly significant difference between the studied groups (p<0.0001). A statistically significant difference was also found when the allelic frequencies between the two groups were compared (p<0.0001), with the A1 allele having a 4.359 fold higher risk of ADHD (Risk Ratio=4.359, 95% CI of RR=3.5753 to 5.3144, Odds Ratio= 7.7824; 95% CI of OR=10.315 to 13.6719). CONCLUSIONS: Our results presented a highly positive correlation between the combined type of ADHD without co-morbidity and ANKK l (DRD2) polymorphism .

000      
00000naa a2200000 a 4500
001      
bmc12025197
003      
CZ-PrNML
005      
20140729134621.0
007      
ta
008      
120816s2010 sw f 000 0#eng||
009      
AR
035    __
$a (PubMed)20150882
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sw
100    1_
$a Paclt, Ivo, $d 1949- $7 jn20000401921 $u Department of Psychiatry, 1st Faculty of Medicine, Charles University Prague, Czech Republic. ivopaclt@seznam.cz
245    14
$a The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years / $c Ivo Paclt, Ivana Drtílková, Marta Kopečková, Pavel Theiner, Omar Šerý, Nikol Čermáková
520    9_
$a OBJECTIVE: The purpose of this study was the correlation of the combined type of ADHD in children and Taq IA polymorphism DRD2 gene. We hypothesized a positive correlation of DRD2 polymorphisms in the combined type of ADHD patients without co-morbidity. PATIENTS AND METHODS: Our research sample included 586 unrelated boys of the Czech origin aged between 6 and 13 years. The ADHD group consisted of 269 boys and the control group consisted of 317 boys. PCR detection of the DRD2 polymorphism was carried out by using primers, described by Grandy (Grandy et al. 1989). RESULTS: The comparison of genotype frequencies showed statistically highly significant difference between the studied groups (p<0.0001). A statistically significant difference was also found when the allelic frequencies between the two groups were compared (p<0.0001), with the A1 allele having a 4.359 fold higher risk of ADHD (Risk Ratio=4.359, 95% CI of RR=3.5753 to 5.3144, Odds Ratio= 7.7824; 95% CI of OR=10.315 to 13.6719). CONCLUSIONS: Our results presented a highly positive correlation between the combined type of ADHD without co-morbidity and ANKK l (DRD2) polymorphism .
650    _2
$a mladiství $7 D000293
650    _2
$a hyperkinetická porucha $x epidemiologie $x genetika $7 D001289
650    _2
$a dítě $7 D002648
650    _2
$a restrikční endonukleasy typu II $x metabolismus $7 D015252
650    _2
$a frekvence genu $7 D005787
650    _2
$a genetická predispozice k nemoci $7 D020022
650    _2
$a genotyp $7 D005838
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a polymorfismus délky restrikčních fragmentů $x fyziologie $7 D012150
650    _2
$a protein-serin-threoninkinasy $x genetika $7 D017346
650    _2
$a receptory dopaminové $x genetika $7 D011954
650    _2
$a receptory dopaminu D2 $x genetika $7 D017448
651    _2
$a Česká republika $x epidemiologie $7 D018153
655    _2
$a časopisecké články $7 D016428
700    1_
$a Drtílková, Ivana, $d 1944- $7 nlk20040156087 $u Department of Psychiatry, Masaryk University, Faculty of Medicine, Brno, Czech Republic
700    1_
$a Kopečková, Marta $7 xx0121589 $u Department of Biology and Medical Genetics, 2nd Faculty of Medicine, Charles University Prague, Czech Republic
700    1_
$a Theiner, Pavel $7 xx0053973 $u Department of Psychiatry, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Šerý, Omar, $d 1972- $7 xx0060835 $u Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk Unviersity, Brno, Czech Republic
700    1_
$a Čermáková, Nikol. $7 xx0258099 $u Department of Psychiatry, 1st Faculty of Medicine, Charles University Prague, Czech Republic
773    0_
$w MED00168352 $t Neuro endocrinology letters $x 0172-780X $g Roč. 31, č. 1 (2010), s. 131-136
856    41
$u https://pubmed.ncbi.nlm.nih.gov/20150882 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m $z 0
990    __
$a 20120816 $b ABA008
991    __
$a 20140729134938 $b ABA008
999    __
$a ok $b bmc $g 947239 $s 782543
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2010 $b 31 $c 1 $d 131-136 $i 0172-780X $m Neuro-endocrinology letters $n Neuro-endocrinol. lett. $x MED00168352
GRA    __
$a NR9534 $p MZ0
LZP    __
$a Pubmed-20120816/10/02

Najít záznam

Citační ukazatele

Možnosti archivace