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Human papillomavirus DNA presence in pelvic lymph nodes in cervical cancer
J. Slama, D. Fischerova, I. Pinkavova, M. Zikan, D. Cibula
Jazyk angličtina Země Spojené státy americké
Typ dokumentu hodnotící studie, časopisecké články, práce podpořená grantem, přehledy
Grantová podpora
NS10037
MZ0
CEP - Centrální evidence projektů
- MeSH
- Alphapapillomavirus genetika izolace a purifikace MeSH
- DNA virů izolace a purifikace MeSH
- infekce papilomavirem diagnóza epidemiologie patologie virologie MeSH
- karcinom diagnóza epidemiologie patologie virologie MeSH
- lidé MeSH
- lymfatické metastázy MeSH
- lymfatické uzliny chemie metabolismus virologie MeSH
- nádory děložního čípku diagnóza epidemiologie patologie virologie MeSH
- pánev MeSH
- prevalence MeSH
- prognóza MeSH
- retrospektivní studie MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- hodnotící studie MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
INTRODUCTION: This work intends to present a systematic overview of data that have been published so far with regard to methods used for tissue sampling and DNA testing and with regard to the prevalence of human papillomavirus (HPV) DNA in pelvic lymph nodes (LNs) and its prognostic significance. METHODS: The HPV DNA status of LN in women with cervical cancer is being explored as a potential marker of "occult" metastases. Although the presence of HPV DNA in LN usually correlates with its metastatic involvement, there is always a subgroup of HPV-positive but histologically negative LNs. RESULTS: The significance of HPV in negative LNs remains uncertain, although several studies have concluded that HPV is a risk factor of recurrence. CONCLUSIONS: A small group size and a short follow-up are the main limitations for drawing any conclusion concerning prognostic significance of the presence of HPV DNA in LNs.
Citace poskytuje Crossref.org
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- $a INTRODUCTION: This work intends to present a systematic overview of data that have been published so far with regard to methods used for tissue sampling and DNA testing and with regard to the prevalence of human papillomavirus (HPV) DNA in pelvic lymph nodes (LNs) and its prognostic significance. METHODS: The HPV DNA status of LN in women with cervical cancer is being explored as a potential marker of "occult" metastases. Although the presence of HPV DNA in LN usually correlates with its metastatic involvement, there is always a subgroup of HPV-positive but histologically negative LNs. RESULTS: The significance of HPV in negative LNs remains uncertain, although several studies have concluded that HPV is a risk factor of recurrence. CONCLUSIONS: A small group size and a short follow-up are the main limitations for drawing any conclusion concerning prognostic significance of the presence of HPV DNA in LNs.
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