• Je něco špatně v tomto záznamu ?

Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy

Jaroslav Sterba, Zdenek Pavelka, Nicolas Andre, Jiri Ventruba, Jarmila Skotakova, Viera Bajciova, Danica Bronisova, Lenka Dubska, Dalibor Valik

. 2010 ; 54 (4) : 616-617.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu kazuistiky, časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc12025431

Grantová podpora
NS9873 MZ0 CEP - Centrální evidence projektů
NR9341 MZ0 CEP - Centrální evidence projektů

Prognosis for children with relapsed medulloblastoma remains poor. Metronomic chemotherapy may offer some benefit to patients treated initially with intensive regimens. However, dosing and duration of such palliative treatment have not been systematically studied. Here we describe a child with medulloblastoma relapsing after initial high-dose chemotherapy and standard radiotherapy. The patient was then treated with metronomic chemotherapy and achieved second complete remission after 21 months of treatment. Three months off therapy he relapsed again and died from progressive disease. This case illustrates the potential benefit of metronomic chemotherapy but also shows the uncertainty of when to stop metronomic chemotherapy while balancing toxicity.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12025431
003      
CZ-PrNML
005      
20140715134637.0
007      
ta
008      
120816s2010 xxu f 000 0#eng||
009      
AR
024    7_
$a 10.1002/pbc.22382 $2 doi
035    __
$a (PubMed)19967772
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Štěrba, Jaroslav, $d 1962- $7 mzk2004237310 $u Pediatric Oncology Department, University Hospital Brno, Masaryk University Brno, Brno, Czech Republic. jsterb@fnbrno.cz
245    10
$a Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy / $c Jaroslav Sterba, Zdenek Pavelka, Nicolas Andre, Jiri Ventruba, Jarmila Skotakova, Viera Bajciova, Danica Bronisova, Lenka Dubska, Dalibor Valik
520    9_
$a Prognosis for children with relapsed medulloblastoma remains poor. Metronomic chemotherapy may offer some benefit to patients treated initially with intensive regimens. However, dosing and duration of such palliative treatment have not been systematically studied. Here we describe a child with medulloblastoma relapsing after initial high-dose chemotherapy and standard radiotherapy. The patient was then treated with metronomic chemotherapy and achieved second complete remission after 21 months of treatment. Three months off therapy he relapsed again and died from progressive disease. This case illustrates the potential benefit of metronomic chemotherapy but also shows the uncertainty of when to stop metronomic chemotherapy while balancing toxicity.
650    _2
$a protokoly antitumorózní kombinované chemoterapie $x aplikace a dávkování $7 D000971
650    _2
$a nádory mozečku $x farmakoterapie $7 D002528
650    _2
$a dítě $7 D002648
650    _2
$a kombinovaná terapie $7 D003131
650    _2
$a léková chronoterapie $7 D055870
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a meduloblastom $x farmakoterapie $7 D008527
650    _2
$a lokální recidiva nádoru $x farmakoterapie $7 D009364
650    _2
$a staging nádorů $7 D009367
650    _2
$a neurochirurgické výkony $7 D019635
650    _2
$a radioterapie $7 D011878
650    _2
$a indukce remise $7 D012074
655    _2
$a kazuistiky $7 D002363
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Pavelka, Zdeněk $7 xx0093082 $u Pediatric Oncology Department, University Hospital Brno, Masaryk University Brno, Brno, Czech Republic
700    1_
$a André, Nicolas $u Pediatric Oncology Department, Hôpital pour Enfants La Timone, Marseille, France $7 gn_A_00006368
700    1_
$a Ventruba, Jiří $7 xx0123567 $u Department of Pediatric Surgery, University Hospital Brno, Brno, Czech Republic
700    1_
$a Skotáková, Jarmila, $d 1957- $7 mzk2004237308 $u Department of Pediatric Radiology, University Hospital Brno, Brno, Czech Republic
700    1_
$a Bajčiová, Viera $7 xx0089689 $u Pediatric Oncology Department, University Hospital Brno, Masaryk University Brno, Brno, Czech Republic
700    1#
$a Zapletalová, Danica. $7 xx0232988 $u Pediatric Oncology Department, University Hospital Brno, Masaryk University Brno, Brno, Czech Republic
700    1_
$a Zdražilová Dubská, Lenka $7 xx0080373 $u Department of Laboratory Medicine, Masaryk Memorial Cancer Institute Brno, Brno, Czech Republic
700    1_
$a Valík, Dalibor $7 xx0061177 $u Department of Laboratory Medicine, Masaryk Memorial Cancer Institute Brno, Brno, Czech Republic
773    0_
$w MED00181047 $t Pediatric blood & cancer $x 1545-5017 $g Roč. 54, č. 4 (2010), s. 616-617
856    41
$u https://pubmed.ncbi.nlm.nih.gov/19967772 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m $z 0
990    __
$a 20120816 $b ABA008
991    __
$a 20140715134936 $b ABA008
999    __
$a ok $b bmc $g 947473 $s 782777
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2010 $b 54 $c 4 $d 616-617 $i 1545-5017 $m Pediatric blood & cancer $n Pediatr Blood Cancer $x MED00181047
GRA    __
$a NS9873 $p MZ0
GRA    __
$a NR9341 $p MZ0
LZP    __
$a Pubmed-20120816/10/02

Najít záznam

Citační ukazatele

Možnosti archivace