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Interaction of common sequence variants and selected risk factors in determination of HDL cholesterol levels

Hirschfeldova Katerina, Sedova Michaela, Vrablik Michal, Svobodova Helena, Zvarova Jana, Hubacek Jaroslav, Ceska Richard

. 2010 ; 43 (9) : 754-758. [pub] 20100413

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc12025788

Grantová podpora
NS10579 MZ0 CEP - Centrální evidence projektů

OBJECTIVES: The aim of our study was to assess the association of common sequence variants, and selected interactions, with HDL-c plasma levels. DESIGN AND METHODS: We analysed 743 individuals (340 men and 403 women) with high mean triglyceride and LDL-c levels. The association of five polymorphic sites (ABCA1 g.1051G>A, APOA1 g.-75G>A, CETP g.-629C>A, HNF1A g.102A>C, and LIPG g.584C>T), apoE isoforms and selected interactions with HDL-c levels were evaluated using linear regression models. RESULTS: After adjusting for triglycerides, sex, and BMI the only genotype with a statistically significant effect on HDL-c levels (p-value=0.004) was the CETP promoter variant. Further, linear regression model with interactions included indicated possible interplay between APOA1 genotype and menopause (p-value=0.002) and ABCA1 and APOE isoforms (p-value=0.017) on HDL-c plasma concentration. CONCLUSIONS: Our study indicated that not only the CETP variant but also apoE isoforms and menopause could operate as potent modulators of HDL-c concentrations.

Citace poskytuje Crossref.org

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