A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.

DUI

D001057 MeSH Prohlížeč

CUI

M0001601

Předchozí užití

Apolipoproteins (1977-1984)

Historická pozn.

1985; for APOLIPOPROTEIN E ISOPROTEINS use APOLIPOPROTEINS E 1985-2006 & use APOLIPOPROTEINS 1983-1984

Veřejná pozn.

1985; APOLIPOPROTEIN E ISOPROTEINS was indexed under APOLIPOPROTEINS E 1985-2006 & under APOLIPOPROTEINS 1983-1984