Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Clinical relevance of KRAS in human cancers

S. Jancík, J. Drábek, D. Radzioch, M. Hajdúch,

. 2010 ; 2010 () : 150960. [pub] 20100607

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc12026262

Grantová podpora
NS9959 MZ0 CEP - Centrální evidence projektů

The KRAS gene (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) is an oncogene that encodes a small GTPase transductor protein called KRAS. KRAS is involved in the regulation of cell division as a result of its ability to relay external signals to the cell nucleus. Activating mutations in the KRAS gene impair the ability of the KRAS protein to switch between active and inactive states, leading to cell transformation and increased resistance to chemotherapy and biological therapies targeting epidermal growth factor receptors. This review highlights some of the features of the KRAS gene and the KRAS protein and summarizes current knowledge of the mechanism of KRAS gene regulation. It also underlines the importance of activating mutations in the KRAS gene in relation to carcinogenesis and their importance as diagnostic biomarkers, providing clues regarding human cancer patients' prognosis and indicating potential therapeutic approaches.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12026262
003      
CZ-PrNML
005      
20140319145147.0
007      
ta
008      
120817e20100607xxu f 000 0#eng||
009      
AR
024    7_
$a 10.1155/2010/150960 $2 doi
035    __
$a (PubMed)20617134
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Jancík, Sylwia $u Laboratory of Experimental Medicine, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and University Hospital, 775 20 Olomouc, Czech Republic.
245    10
$a Clinical relevance of KRAS in human cancers / $c S. Jancík, J. Drábek, D. Radzioch, M. Hajdúch,
520    9_
$a The KRAS gene (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) is an oncogene that encodes a small GTPase transductor protein called KRAS. KRAS is involved in the regulation of cell division as a result of its ability to relay external signals to the cell nucleus. Activating mutations in the KRAS gene impair the ability of the KRAS protein to switch between active and inactive states, leading to cell transformation and increased resistance to chemotherapy and biological therapies targeting epidermal growth factor receptors. This review highlights some of the features of the KRAS gene and the KRAS protein and summarizes current knowledge of the mechanism of KRAS gene regulation. It also underlines the importance of activating mutations in the KRAS gene in relation to carcinogenesis and their importance as diagnostic biomarkers, providing clues regarding human cancer patients' prognosis and indicating potential therapeutic approaches.
650    _2
$a lidé $7 D006801
650    _2
$a nádory $x genetika $x metabolismus $x terapie $7 D009369
650    _2
$a protoonkogenní proteiny $7 D011518
650    _2
$a ras proteiny $7 D018631
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a přehledy $7 D016454
700    1_
$a Drábek, Jirí
700    1_
$a Radzioch, Danuta
700    1_
$a Hajdúch, Marián
773    0_
$w MED00008233 $t Journal of biomedicine & biotechnology $x 1110-7251 $g Roč. 2010(20100607), s. 150960
856    41
$u https://pubmed.ncbi.nlm.nih.gov/20617134 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m $z 0
990    __
$a 20120817 $b ABA008
991    __
$a 20140319145213 $b ABA008
999    __
$a ok $b bmc $g 948304 $s 783608
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2010 $b 2010 $d 150960 $e 20100607 $i 1110-7251 $m Journal of biomedicine and biotechnology $n J Biomed Biotechnol $x MED00008233
GRA    __
$a NS9959 $p MZ0
LZP    __
$a Pubmed-20120817/10/04

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace