• Something wrong with this record ?

Modified porphyrin-brucine conjugated to gold nanoparticles and their application in photodynamic therapy

K. Záruba, J. Králová, P. Rezanka, P. Poucková, L. Veverková, V. Král,

. 2010 ; 8 (14) : 3202-6. [pub] 20100520

Language English Country England, Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc12026386

Two porphyrin-brucine quaternary ammonium salts were immobilized on gold nanoparticles and their suitability for both in vitro and in vivo photodynamic therapy (PDT) was assayed using the basaloid squamous cell carcinoma PE/CA-PJ34 cell line. In vitro PDT experiments revealed that the gold nanoparticle-bound conjugates were less effective than unbound conjugates in killing cells. However, the same conjugates were more effective in reducing tumor size in vivo, with complete tumor regression observed.

000      
00000naa a2200000 a 4500
001      
bmc12026386
003      
CZ-PrNML
005      
20121001194115.0
007      
ta
008      
120817e20100520enk f 000 0#eng||
009      
AR
035    __
$a (PubMed)20485822
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Záruba, Kamil, $d 1976- $7 mzk2006355976 $u Department of Analytical Chemistry, Faculty of Chemical Engineering, Institute of Chemical Technology Prague, Technická 5, 166 28 Prague 6. kamil.zaruba@vscht.cz
245    10
$a Modified porphyrin-brucine conjugated to gold nanoparticles and their application in photodynamic therapy / $c K. Záruba, J. Králová, P. Rezanka, P. Poucková, L. Veverková, V. Král,
520    9_
$a Two porphyrin-brucine quaternary ammonium salts were immobilized on gold nanoparticles and their suitability for both in vitro and in vivo photodynamic therapy (PDT) was assayed using the basaloid squamous cell carcinoma PE/CA-PJ34 cell line. In vitro PDT experiments revealed that the gold nanoparticle-bound conjugates were less effective than unbound conjugates in killing cells. However, the same conjugates were more effective in reducing tumor size in vivo, with complete tumor regression observed.
650    _2
$a alkylace $7 D000478
650    _2
$a zvířata $7 D000818
650    _2
$a biologický transport $7 D001692
650    _2
$a buněčná smrt $x účinky léků $x účinky záření $7 D016923
650    _2
$a nádorové buněčné linie $7 D045744
650    _2
$a zlato $x chemie $7 D006046
650    _2
$a lidé $7 D006801
650    _2
$a intracelulární prostor $x metabolismus $7 D042541
650    _2
$a kovové nanočástice $x chemie $7 D053768
650    _2
$a myši $7 D051379
650    _2
$a nádory $x farmakoterapie $7 D009369
650    _2
$a fotochemoterapie $x metody $7 D010778
650    _2
$a porfyriny $x chemie $7 D011166
650    _2
$a rozpouštědla $x chemie $7 D012997
650    _2
$a strychnin $x analogy a deriváty $x chemie $x metabolismus $x farmakologie $x terapeutické užití $7 D013331
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Králová, Jarmila
700    1_
$a Rezanka, Pavel
700    1_
$a Poucková, Pavla
700    1_
$a Veverková, Lenka
700    1_
$a Král, Vladimír, $d 1949-2019 $7 jo20010088887
773    0_
$w MED00007088 $t Organic & biomolecular chemistry $x 1477-0539 $g Roč. 8, č. 14 (20100520), s. 3202-6
856    41
$u https://pubmed.ncbi.nlm.nih.gov/20485822 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m
990    __
$a 20120817 $b ABA008
991    __
$a 20121001194308 $b ABA008
999    __
$a ok $b bmc $g 948428 $s 783732
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2010 $b 8 $c 14 $d 3202-6 $e 20100520 $i 1477-0539 $m Organic & biomolecular chemistry $n Org Biomol Chem $x MED00007088
LZP    __
$a Pubmed-20120817/10/04

Find record

Citation metrics

Archiving options