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Experience with a naphthylmedetomidine-ketamine-hyaluronidase combination in inducing immobilization in anthropoid apes
L. Hess, M. Votava, J. Schreiberová, J. Málek, M. Horáček,
Language English Country Denmark
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
Grant support
NR9168
MZ0
CEP Register
Digital library NLK
Full text - Article
Source
NLK
Medline Complete (EBSCOhost)
from 1998-02-01 to 1 year ago
Wiley Online Library (archiv)
from 1997-01-01 to 2012-12-31
- MeSH
- Hyaluronoglucosaminidase administration & dosage MeSH
- Immobilization methods veterinary MeSH
- Ketamine administration & dosage MeSH
- Medetomidine administration & dosage analogs & derivatives MeSH
- Pan troglodytes MeSH
- Pongo MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
BACKGROUND: The aim of the study was to compare the effect of naphthylmedetomidine to medetomidine on the behavior of orangutans and chimpanzees. METHODS: The immobilization was performed as part of a medical examination in five chimpanzees and three orangutans. Following pre-medication with midazolam (0.70-1.20 mg/kg p.o.), naphthylmedetomidine (50-70 microg/kg), or medetomidine (20-30 microg/kg) was given with ketamine (3 mg/kg) and hyaluronidase (150 M.U.) into musculus deltoideus. RESULTS: We observed the distinct anti-aggressive effect of naphthylmedetomidine. The immobilization with naphthylmedetomidine was shallower and the influence on cardiac frequency less substantial compared to medetomidine. The overall sedative effect of naphthylmedetomidine lasted for less time, and its effect was incompletely antagonized with atipamezole in comparison to medetomidine. CONCLUSIONS: Naphthylmedetomidine could replace medetomidine for inducing immobilization and sedation. A combination of naphthylmedetomidine-ketamine is suitable for relocating animals to other cages or for painless medical examinations.
References provided by Crossref.org
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- $a BACKGROUND: The aim of the study was to compare the effect of naphthylmedetomidine to medetomidine on the behavior of orangutans and chimpanzees. METHODS: The immobilization was performed as part of a medical examination in five chimpanzees and three orangutans. Following pre-medication with midazolam (0.70-1.20 mg/kg p.o.), naphthylmedetomidine (50-70 microg/kg), or medetomidine (20-30 microg/kg) was given with ketamine (3 mg/kg) and hyaluronidase (150 M.U.) into musculus deltoideus. RESULTS: We observed the distinct anti-aggressive effect of naphthylmedetomidine. The immobilization with naphthylmedetomidine was shallower and the influence on cardiac frequency less substantial compared to medetomidine. The overall sedative effect of naphthylmedetomidine lasted for less time, and its effect was incompletely antagonized with atipamezole in comparison to medetomidine. CONCLUSIONS: Naphthylmedetomidine could replace medetomidine for inducing immobilization and sedation. A combination of naphthylmedetomidine-ketamine is suitable for relocating animals to other cages or for painless medical examinations.
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- $a Votava, M. $u Department of Pharmacology, 3rd Faculty of Medicine, Charles University, Prague, Czech
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- $a Schreiberová, J. $u Department of Anaesthesiology and Intensive Care Medicine Charles, Faculty of Medicine and University Hospital Hradec Králové, University in Prague, Hradec Králové, Czech
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- $a Málek, J. $u Department of Anaesthesiology and Critical Care Medicine, 3rd Faculty of Medicine, Charles University in Prague, Prague, Czech
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