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A clinically relevant, syngeneic model of spontaneous, highly metastatic B16 mouse melanoma
V. Bobek, K. Kolostova, D. Pinterova, G. Kacprzak, J. Adamiak, J. Kolodziej, M. Boubelik, M. Kubecova, R. M. Hoffman
Language English Country Greece
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NS9976
MZ0
CEP Register
Digital library NLK
Full text - Article
Source
NLK
Free Medical Journals
from 2004 to 2 years ago
Open Access Digital Library
from 2004-01-01
PubMed
21187455
Knihovny.cz E-resources
- MeSH
- Lymphatic Metastasis MeSH
- Melanoma, Experimental pathology secondary MeSH
- Disease Models, Animal MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Cell Line, Tumor MeSH
- Neoplasm Transplantation MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
We report a syngeneic model of spontaneous metastatic B16-F10 mouse melanoma in C57/BL6 mice with a very high metastatic frequency that mimics clinical metastatic melanoma. The B16 melanoma cells were injected between the skin and cartilage on the dorsal side of the ear. The model generated lymphatic and visceral metastases in all of the tested animals. In mice with large primary tumors, tumor weight correlated with the tumor growth time and also with the number of metastases in lymph nodes and organs. The dorsal ear space between the skin and cartilage enables both lymphatic and hematogenous metastatic spread. The model should be useful to study the mechanism of melanoma metastasis and to develop therapy for this currently untreatable disease.
AntiCancer Inc 7917 Ostrow St San Diego CA 92111 U S A
Department of Surgery University of California San Diego CA 92103 8220 U S A
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- $a Bobek, Vladimír $7 xx0162734 $u Department of Tumor Biology, Third Faculty of Medicine Charles University, Ruska 87, 100 34 Prague, Czech Republic. vbobek@centrum.cz; Department of Thoracic Surgery, Lower Silesian Centre of Lung Diseases, Medical University Wroclaw, 53-439 Wroclaw, Poland
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- $a A clinically relevant, syngeneic model of spontaneous, highly metastatic B16 mouse melanoma / $c V. Bobek, K. Kolostova, D. Pinterova, G. Kacprzak, J. Adamiak, J. Kolodziej, M. Boubelik, M. Kubecova, R. M. Hoffman
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- $a We report a syngeneic model of spontaneous metastatic B16-F10 mouse melanoma in C57/BL6 mice with a very high metastatic frequency that mimics clinical metastatic melanoma. The B16 melanoma cells were injected between the skin and cartilage on the dorsal side of the ear. The model generated lymphatic and visceral metastases in all of the tested animals. In mice with large primary tumors, tumor weight correlated with the tumor growth time and also with the number of metastases in lymph nodes and organs. The dorsal ear space between the skin and cartilage enables both lymphatic and hematogenous metastatic spread. The model should be useful to study the mechanism of melanoma metastasis and to develop therapy for this currently untreatable disease.
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