BACKGROUND: Narcolepsy is associated with altered metabolic functions. We sought to investigate the effect of narcolepsy on pregnancy and newborns. MATERIAL/METHODS: A retrospective cohort study of patients in whom the first symptoms of narcolepsy appeared before or after pregnancy. Our study included 54 women, mothers of a total of 110 children (37 with symptoms of narcolepsy before and during pregnancy, 17 developed the narcolepsy syndrome only after childbirth). With only 1 exception, none of the patients were treated with drugs during pregnancy. RESULTS: We did not find any significant differences between the 2 groups in the registered parameters of: age of mothers at delivery, history of spontaneous abortion, alcohol and nicotine consumption, medication, complications during pregnancy, symptoms of narcolepsy, weight gain during pregnancy, length of pregnancy and delivery, complications during delivery, and weight and length of the newborn. The women experiencing symptoms of narcolepsy before or during pregnancy were found to have a significantly higher total number of pregnancy complications (35.8%) than those with later onset of symptoms (9.1%), although the complications were not clinically significant. More patients in the symptomatic group tended to have impaired glucose tolerance or type 2 diabetes, compared to the asymptomatic group. CONCLUSIONS: The study revealed no clinically relevant adverse effects of narcolepsy on pregnancy, childbirth or the newborn.

Department of Neurology 1st Faculty of Medicine Charles University Prague Prague Czech Republic

Department of Neurology 1st Medical Faculty Charles University Katerinská 30 12000 Prague 2 Czech Republic

Department of Neurology and Center of clinical Neuroscience 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic

Department of Neurology Faculty of Medicine P J Safarik University Kosice Slovakia

epartment of Neurology Faculty Hospital Ostrava