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Early morphogenesis of heterodont dentition in minipigs
J. Stembírek, M. Buchtová, T. Král, E. Matalová, S. Lozanoff, I. Míšek
Language English Country Denmark
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Basement Membrane embryology MeSH
- Cell Differentiation physiology MeSH
- Dentin embryology MeSH
- Epithelium embryology MeSH
- Mesoderm embryology MeSH
- Swine, Miniature MeSH
- Models, Animal MeSH
- Morphogenesis physiology MeSH
- Odontoblasts cytology MeSH
- Odontogenesis physiology MeSH
- Enamel Organ embryology MeSH
- Image Processing, Computer-Assisted methods MeSH
- Swine MeSH
- Bicuspid embryology MeSH
- Cell Proliferation MeSH
- Proliferating Cell Nuclear Antigen analysis MeSH
- Incisor embryology MeSH
- Cuspid embryology MeSH
- Imaging, Three-Dimensional methods MeSH
- Tooth Germ embryology MeSH
- Tooth, Deciduous embryology MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
The minipig provides an excellent experimental model for tooth morphogenesis because its diphyodont and heterodont dentition resemble that of humans. However, little information is available on the processes of tooth development in the pig. The purpose of this study was to classify the early stages of odontogenesis in minipigs from the initiation of deciduous dentition to the late bell stage when the successional dental lamina begins to develop. To analyze the initiation of teeth anlagens and the structural changes of dental lamina, a three-dimensional (3D) analysis was performed. At the earliest stage, 3D reconstruction revealed a continuous dental lamina along the length of the jaw. Later, the dental lamina exhibited remarkable differences in depth, and the interdental lamina was shorter. The dental lamina grew into the mesenchyme in the lingual direction, and its inclined growth was underlined by asymmetrical cell proliferation. After the primary tooth germ reached the late bell stage, the dental lamina began to disintegrate and fragmentize. Some cells disappeared during the process of lamina degradation, while others remained in small islands known as epithelial pearls. The minipig can therefore, inter alia, be used as a model organism to study the fate of epithelial pearls from their initiation to their contribution to pathological structures, primarily because of the clinical significance of these epithelial rests.
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- $a The minipig provides an excellent experimental model for tooth morphogenesis because its diphyodont and heterodont dentition resemble that of humans. However, little information is available on the processes of tooth development in the pig. The purpose of this study was to classify the early stages of odontogenesis in minipigs from the initiation of deciduous dentition to the late bell stage when the successional dental lamina begins to develop. To analyze the initiation of teeth anlagens and the structural changes of dental lamina, a three-dimensional (3D) analysis was performed. At the earliest stage, 3D reconstruction revealed a continuous dental lamina along the length of the jaw. Later, the dental lamina exhibited remarkable differences in depth, and the interdental lamina was shorter. The dental lamina grew into the mesenchyme in the lingual direction, and its inclined growth was underlined by asymmetrical cell proliferation. After the primary tooth germ reached the late bell stage, the dental lamina began to disintegrate and fragmentize. Some cells disappeared during the process of lamina degradation, while others remained in small islands known as epithelial pearls. The minipig can therefore, inter alia, be used as a model organism to study the fate of epithelial pearls from their initiation to their contribution to pathological structures, primarily because of the clinical significance of these epithelial rests.
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