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Sensitivity of endogenous autofluorescence in HeLa cells to the application of external magnetic fields

M. Uzhytchak, B. Smolková, A. Frtús, A. Stupakov, M. Lunova, F. Scollo, M. Hof, P. Jurkiewicz, GJ. Sullivan, A. Dejneka, O. Lunov

. 2023 ; 13 (1) : 10818. [pub] 20230704

Language English Country England, Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc23016928

Dramatically increased levels of electromagnetic radiation in the environment have raised concerns over the potential health hazards of electromagnetic fields. Various biological effects of magnetic fields have been proposed. Despite decades of intensive research, the molecular mechanisms procuring cellular responses remain largely unknown. The current literature is conflicting with regards to evidence that magnetic fields affect functionality directly at the cellular level. Therefore, a search for potential direct cellular effects of magnetic fields represents a cornerstone that may propose an explanation for potential health hazards associated with magnetic fields. It has been proposed that autofluorescence of HeLa cells is magnetic field sensitive, relying on single-cell imaging kinetic measurements. Here, we investigate the magnetic field sensitivity of an endogenous autofluorescence in HeLa cells. Under the experimental conditions used, magnetic field sensitivity of an endogenous autofluorescence was not observed in HeLa cells. We present a number of arguments indicating why this is the case in the analysis of magnetic field effects based on the imaging of cellular autofluorescence decay. Our work indicates that new methods are required to elucidate the effects of magnetic fields at the cellular level.

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$a Smolková, Barbora $u Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, Prague, 18221, Czech Republic
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$a Frtús, Adam $u Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, Prague, 18221, Czech Republic
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$a Stupakov, Alexandr $u Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, Prague, 18221, Czech Republic
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$a Lunova, Mariia $u Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, Prague, 18221, Czech Republic $u Institute for Clinical and Experimental Medicine (IKEM), Prague, 14021, Czech Republic
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$a Scollo, Federica $u J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, 18223, Czech Republic
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$a Hof, Martin $u J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, 18223, Czech Republic
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$a Jurkiewicz, Piotr $u J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, 18223, Czech Republic
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$a Sullivan, Gareth John $u Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway $u Department of Pediatric Research, Oslo University Hospital, Oslo, Norway $u Department of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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