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3,5-disubstituted pyranone analogues of highly antifungally active furanones: conversion of biological effect from antifungal to cytostatic
R. Schiller, L. Tichotová, J. Pavlík, V. Buchta, B. Melichar, I. Votruba, J. Kunes, M. Spulák, M. Pour
Bioorganic & medicinal chemistry letters.
2010 ;
20 (24) :
7358-7360.
[pub] 20101021
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/bmc12026660
- MeSH
- Antifungal Agents chemical synthesis chemistry pharmacology MeSH
- Cytostatic Agents chemical synthesis chemistry pharmacology MeSH
- Furans chemical synthesis chemistry pharmacology MeSH
- Humans MeSH
- Mice MeSH
- Cell Line, Tumor MeSH
- Pyrans chemistry MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
A series of 3-aryl-5-acyloxymethyl-5,6-dihydro-2H-pyran-2-ones, related to highly antifungally active butenolides, was synthesized via cyclization of substituted δ-hydroxy acids as the key step, and evaluated for their in vitro antifungal activity and cytostatic activity. While the extension of the furanone ring to pyranone led to a complete loss of the antifungal effect, some of the compounds displayed promising effect against several cell lines, including the resistant colorectal carcinoma cells.
References provided by Crossref.org
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