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3,5-disubstituted pyranone analogues of highly antifungally active furanones: conversion of biological effect from antifungal to cytostatic
R. Schiller, L. Tichotová, J. Pavlík, V. Buchta, B. Melichar, I. Votruba, J. Kunes, M. Spulák, M. Pour
Bioorganic & medicinal chemistry letters.
2010 ;
20 (24) :
7358-7360.
[pub] 20101021
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc12026660
- MeSH
- antifungální látky chemická syntéza chemie farmakologie MeSH
- cytostatické látky chemická syntéza chemie farmakologie MeSH
- furany chemická syntéza chemie farmakologie MeSH
- lidé MeSH
- myši MeSH
- nádorové buněčné linie MeSH
- pyrany chemie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
A series of 3-aryl-5-acyloxymethyl-5,6-dihydro-2H-pyran-2-ones, related to highly antifungally active butenolides, was synthesized via cyclization of substituted δ-hydroxy acids as the key step, and evaluated for their in vitro antifungal activity and cytostatic activity. While the extension of the furanone ring to pyranone led to a complete loss of the antifungal effect, some of the compounds displayed promising effect against several cell lines, including the resistant colorectal carcinoma cells.
Citace poskytuje Crossref.org
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