• Je něco špatně v tomto záznamu ?

Uterine tumors with neuroectodermal differentiation. A report of 4 cases

P. Dundr, D. Fischerová, C. Povýšil, A. Berková, L. Bauerová, D. Cibula

. 2010 ; 16 (4) : 601-608. [pub] 20100305

Jazyk angličtina Země Nizozemsko

Typ dokumentu kazuistiky, časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc12026956

We report four cases of uterine tumors with neuroectodermal differentiation. One tumor had neuroectodermal component only; in the three other tumors, the neuroectodermal component was admixed with another component, namely rhabdomyosarcoma (1 case), and endometrioid adenocarcinoma (2 cases). Histologically, the neuroectodermal component consisted of small to medium sized cells arranged in diffuse sheets. The tumor cells had round nuclei with stippled to coarsely granular chromatin, mostly with non-prominent nucleoli, and scant eosinophilic or amphophilic cytoplasm. Immunohistochemically, 4/4 tumors showed expression of vimentin, synaptophysin and CD56; 3/4 tumors were CD99 and NSE positive; 2/4 tumors showed focal expression of S-100 protein; and 1/4 tumors had focal dot-like cytoplasmic positivity for cytokeratin AE1/AE3. FLI-1 was negative in all cases. FISH examination was performed and none of the tumors showed rearrangement of EWSR1 gene. Uterine tumors with neuroectodermal differentiation are rare; to the best of our knowledge only 44 cases have been reported in the literature to date, referred to as Ewing sarcoma, peripheral PNET (pPNET), PNET (not otherwise specified) and uterine tumors with neuroendocrine differentiation.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12026956
003      
CZ-PrNML
005      
20241204104206.0
007      
ta
008      
120816s2010 ne f 000 0#eng||
009      
AR
024    7_
$a 10.1007/s12253-010-9249-7 $2 doi
035    __
$a (PubMed)20204716
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Dundr, Pavel $7 xx0080436 $u Department of Pathology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Studničkova 2, Prague 128 00, Czech Republic. pdundr@seznam.cz
245    10
$a Uterine tumors with neuroectodermal differentiation. A report of 4 cases / $c P. Dundr, D. Fischerová, C. Povýšil, A. Berková, L. Bauerová, D. Cibula
520    9_
$a We report four cases of uterine tumors with neuroectodermal differentiation. One tumor had neuroectodermal component only; in the three other tumors, the neuroectodermal component was admixed with another component, namely rhabdomyosarcoma (1 case), and endometrioid adenocarcinoma (2 cases). Histologically, the neuroectodermal component consisted of small to medium sized cells arranged in diffuse sheets. The tumor cells had round nuclei with stippled to coarsely granular chromatin, mostly with non-prominent nucleoli, and scant eosinophilic or amphophilic cytoplasm. Immunohistochemically, 4/4 tumors showed expression of vimentin, synaptophysin and CD56; 3/4 tumors were CD99 and NSE positive; 2/4 tumors showed focal expression of S-100 protein; and 1/4 tumors had focal dot-like cytoplasmic positivity for cytokeratin AE1/AE3. FLI-1 was negative in all cases. FISH examination was performed and none of the tumors showed rearrangement of EWSR1 gene. Uterine tumors with neuroectodermal differentiation are rare; to the best of our knowledge only 44 cases have been reported in the literature to date, referred to as Ewing sarcoma, peripheral PNET (pPNET), PNET (not otherwise specified) and uterine tumors with neuroendocrine differentiation.
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a proteiny vázající kalmodulin $x genetika $7 D002148
650    _2
$a buněčná diferenciace $x fyziologie $7 D002454
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a genová přestavba $7 D015321
650    _2
$a lidé $7 D006801
650    _2
$a imunohistochemie $7 D007150
650    _2
$a lidé středního věku $7 D008875
650    _2
$a neuroektodermové nádory $x genetika $x patologie $7 D017599
650    _2
$a proteiny vázající RNA $x genetika $7 D016601
650    _2
$a nádory dělohy $x genetika $x patologie $7 D014594
655    _2
$a kazuistiky $7 D002363
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Fischerová, Daniela $7 xx0074804 $u Oncogynecological Centre, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague
700    1_
$a Povýšil, Ctibor, $d 1943- $7 jn20001103579 $u Department of Pathology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague
700    1_
$a Berková, Adéla $7 xx0325890 $u 1st Department of Medicine—Department of Haematology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague
700    1_
$a Bauerová, Lenka $7 xx0240645 $u Department of Pathology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague
700    1_
$a Cibula, David, $d 1968- $7 jo20000074072 $u Oncogynecological Centre, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague
773    0_
$w MED00180530 $t Pathology oncology research $x 1532-2807 $g Roč. 16, č. 4 (2010), s. 601-608
856    41
$u https://pubmed.ncbi.nlm.nih.gov/20204716 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m $z 0
990    __
$a 20120816 $b ABA008
991    __
$a 20241204104201 $b ABA008
999    __
$a ok $b bmc $g 948998 $s 784302
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2010 $b 16 $c 4 $d 601-608 $e 20100305 $i 1532-2807 $m Pathology oncology research $n Pathol Oncol Res $x MED00180530
LZP    __
$b NLK122 $a Pubmed-20120816/11/01

Najít záznam

Citační ukazatele

Možnosti archivace