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Circulating serum matrix metalloproteinase-3 and metalloproteinase-9 are not associated with echocardiographic parameters of diastolic function in asymptomatic type 2 diabetic patients
E. Zákovičová, J. Charvat, J. Kukacka, J. Chlumsky, P. Svab, M. Kvapil
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 2000
Open Access Digital Library
from 1972-11-01
ROAD: Directory of Open Access Scholarly Resources
from 1972
- MeSH
- Antihypertensive Agents therapeutic use MeSH
- Diabetes Mellitus, Type 2 blood enzymology physiopathology ultrasonography MeSH
- Diastole MeSH
- Echocardiography MeSH
- Hypolipidemic Agents therapeutic use MeSH
- Cardiovascular Diseases complications drug therapy physiopathology ultrasonography MeSH
- Middle Aged MeSH
- Humans MeSH
- Matrix Metalloproteinase 3 blood MeSH
- Matrix Metalloproteinase 9 blood MeSH
- Case-Control Studies MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Serum concentrations of matrix metalloproteinase (MMP) 3 and MMP9 were evaluated in 82 asymptomatic type 2 diabetes mellitus patients without cardiovascular complications and in 41 non-diabetic control subjects. In the asymptomatic diabetic patients, the correlations of these concentrations with diabetes duration, selected biochemical parameters such as glycated haemoglobin (HbA(1c)), and echocardiographic parameters of diastolic function were also assessed. Pulsed and tissue Doppler echocardiography was performed in the two groups. Mean ± SD age was 61 ± 6 years for the asymptomatic diabetic patients and 61 ± 5 years for controls. Mean ± SD concentrations of MMP3 and MMP9 were significantly higher in the asymptomatic diabetic patients (67.5 ± 10.4 and 77.8 ± 28.8 μg/l, respectively) than in controls (47.2 ± 6.1 and 51.1 ± 13.7 μg/l, respectively). In the asymptomatic diabetic patients, MMP3 correlated only with albuminuria (r = 0.341) and MMP9 only with HbA(1c) (r = 0.262); neither MMP was correlated with echocardiographic parameters of diastolic function. Thus, in asymptomatic type 2 diabetic patients without cardiovascular complications, serum MMP3 and MMP9 were elevated, MMP9 was associated with HbA(1c) and MMP3 was associated with albuminuria, however, MMP3 and MMP9 were not associated with echocardiographic parameters of diastolic function.
Department of Medicine 2 2nd Medical Faculty Charles University Prague Czech Republic
Department of Medicine Motol University Hospital Charles University Prague Czech Republic
Medical Department 2nd Faculty Hospital Charles University Prague Czech Republic
Medical Department 2nd Faculty of Medicine Charles University Prague Czech Republic
References provided by Crossref.org
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