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Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission
A. Schwarz, JA. Juarez, J. Richards, B. Rath, VQ. Machaca, YE. Castro, ES. Málaga, K. Levy, RH. Gilman, C. Bern, M. Verastegui, MZ. Levy,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
- MeSH
- Chagasova nemoc prevence a kontrola MeSH
- dezinsekce metody MeSH
- imunoanalýza MeSH
- kousnutí a bodnutí hmyzem imunologie prevence a kontrola MeSH
- morčata MeSH
- parazitologie metody MeSH
- sítě nad lůžka napuštěné insekticidy MeSH
- sliny imunologie MeSH
- Triatoma imunologie MeSH
- zvířata MeSH
- Check Tag
- morčata MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Geografické názvy
- Peru MeSH
Insecticide-impregnated nets can kill triatomine bugs, but it remains unclear whether they can protect against Chagas disease transmission. In a field trial in Quequeña, Peru, sentinel guinea pigs placed in intervention enclosures covered by deltamethrin-treated nets showed significantly lower antibody responses to saliva of Triatoma infestans compared with animals placed in pre-existing control enclosures. Our results strongly suggest that insecticide-treated nets prevent triatomine bites and can thereby protect against infection with Trypanosoma cruzi. Anti-salivary immunoassays are powerful new tools to evaluate intervention strategies against Chagas disease.
Citace poskytuje Crossref.org
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- $a Insecticide-impregnated nets can kill triatomine bugs, but it remains unclear whether they can protect against Chagas disease transmission. In a field trial in Quequeña, Peru, sentinel guinea pigs placed in intervention enclosures covered by deltamethrin-treated nets showed significantly lower antibody responses to saliva of Triatoma infestans compared with animals placed in pre-existing control enclosures. Our results strongly suggest that insecticide-treated nets prevent triatomine bites and can thereby protect against infection with Trypanosoma cruzi. Anti-salivary immunoassays are powerful new tools to evaluate intervention strategies against Chagas disease.
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