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Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission
A. Schwarz, JA. Juarez, J. Richards, B. Rath, VQ. Machaca, YE. Castro, ES. Málaga, K. Levy, RH. Gilman, C. Bern, M. Verastegui, MZ. Levy,
Language English Country England, Great Britain
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
- MeSH
- Chagas Disease prevention & control MeSH
- Insect Control methods MeSH
- Immunoassay MeSH
- Insect Bites and Stings immunology prevention & control MeSH
- Guinea Pigs MeSH
- Parasitology methods MeSH
- Insecticide-Treated Bednets MeSH
- Saliva immunology MeSH
- Triatoma immunology MeSH
- Animals MeSH
- Check Tag
- Guinea Pigs MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
- Geographicals
- Peru MeSH
Insecticide-impregnated nets can kill triatomine bugs, but it remains unclear whether they can protect against Chagas disease transmission. In a field trial in Quequeña, Peru, sentinel guinea pigs placed in intervention enclosures covered by deltamethrin-treated nets showed significantly lower antibody responses to saliva of Triatoma infestans compared with animals placed in pre-existing control enclosures. Our results strongly suggest that insecticide-treated nets prevent triatomine bites and can thereby protect against infection with Trypanosoma cruzi. Anti-salivary immunoassays are powerful new tools to evaluate intervention strategies against Chagas disease.
References provided by Crossref.org
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