-
Something wrong with this record ?
A novel DTPA cross-linking of hyaluronic acid and metal complexation thereof
R. Buffa, J. Běťák, S. Kettou, M. Hermannová, L. Pospíšilová, V. Velebný,
Language English Country Netherlands
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Hyaluronic Acid chemistry MeSH
- Pentetic Acid chemistry MeSH
- Magnetic Resonance Spectroscopy MeSH
- Molecular Structure MeSH
- Spectroscopy, Fourier Transform Infrared MeSH
- Temperature MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Macromolecular conjugates of a natural polysaccharide, hyaluronic acid, with diethylenetriaminepentaacetic acid (DTPA)-metal complexes were synthesized and characterized by FTIR, NMR, SEC-MALLS and ICP analysis. Several parameters of the cross-linking reaction as molecular weight of starting HA, temperature, equivalent of DTPA bis-anhydride, concentration of HA, presence of transacylation catalyst DMAP and reaction time were studied. The mechanism for the reaction was suggested and relationship between the molecular weight assigned by SEC-MALLS, reaction parameters and rheological properties of the final cross-linked products were investigated.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc12028291
- 003
- CZ-PrNML
- 005
- 20250318144800.0
- 007
- ta
- 008
- 120817s2011 ne f 000 0#eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.carres.2011.04.015 $2 doi
- 035 __
- $a (PubMed)21621751
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Buffa, Radovan $u R&D Department, CPN s.r.o, Dolní Dobrouč 401, Dolní Dobrouč, Czech Republic. buffa@contipro.cz $7 xx0330178
- 245 12
- $a A novel DTPA cross-linking of hyaluronic acid and metal complexation thereof / $c R. Buffa, J. Běťák, S. Kettou, M. Hermannová, L. Pospíšilová, V. Velebný,
- 520 9_
- $a Macromolecular conjugates of a natural polysaccharide, hyaluronic acid, with diethylenetriaminepentaacetic acid (DTPA)-metal complexes were synthesized and characterized by FTIR, NMR, SEC-MALLS and ICP analysis. Several parameters of the cross-linking reaction as molecular weight of starting HA, temperature, equivalent of DTPA bis-anhydride, concentration of HA, presence of transacylation catalyst DMAP and reaction time were studied. The mechanism for the reaction was suggested and relationship between the molecular weight assigned by SEC-MALLS, reaction parameters and rheological properties of the final cross-linked products were investigated.
- 650 _2
- $a kyselina hyaluronová $x chemie $7 D006820
- 650 _2
- $a magnetická rezonanční spektroskopie $7 D009682
- 650 _2
- $a molekulární struktura $7 D015394
- 650 _2
- $a kyselina pentetová $x chemie $7 D004369
- 650 _2
- $a spektroskopie infračervená s Fourierovou transformací $7 D017550
- 650 _2
- $a teplota $7 D013696
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Běťák, Jiří
- 700 1_
- $a Kettou, Sofiane
- 700 1_
- $a Hermannová, Martina
- 700 1_
- $a Pospíšilová, Lucie
- 700 1_
- $a Velebný, Vladimír
- 773 0_
- $w MED00001049 $t Carbohydrate research $x 1873-426X $g Roč. 346, č. 13 (2011), s. 1909-15
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/21621751 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y m $z 0
- 990 __
- $a 20120817 $b ABA008
- 991 __
- $a 20250318144757 $b ABA008
- 999 __
- $a ok $b bmc $g 950333 $s 785637
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2011 $b 346 $c 13 $d 1909-15 $e 20110420 $i 1873-426X $m Carbohydrate research $n Carbohydr Res $x MED00001049
- LZP __
- $a Pubmed-20120817/11/04
