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Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces
T. Rezanka, L. Siristova, O. Schreiberová, M. Rezanka, J. Masák, K. Melzoch, K. Sigler,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- Alicyclobacillus metabolismus MeSH
- antibakteriální látky biosyntéza MeSH
- butyráty metabolismus MeSH
- ivermektin analogy a deriváty metabolismus MeSH
- kyseliny pentanové metabolismus MeSH
- mastné kyseliny biosyntéza MeSH
- Rhodococcus metabolismus MeSH
- Streptomyces metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
A biosynthetic pathway using pivalic acid as a starter unit was found in three bacterial species, Alicyclobacillus acidoterrestris, Rhodococcus erythropolis and Streptomyces avermitilis. When deuterium-labelled pivalic acid was added to A. acidoterrestris and R. erythropolis nutrient media it was incorporated into fatty acids to give rise to tert-butyl fatty acids (t-FAs). In addition, in R. erythropolis, pivalic acid was transformed into two starter units, i.e. isobutyric and 2-methylbutyric acid, which served as precursors of corresponding iso-even FAs and anteiso-FAs. In S. avermitilis the biosynthesis also yielded all three branched FAs; apart from this pathway, both pivalic and 2-methylbutyric acids were incorporated into the antibiotic avermectin.
Citace poskytuje Crossref.org
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