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Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces
T. Rezanka, L. Siristova, O. Schreiberová, M. Rezanka, J. Masák, K. Melzoch, K. Sigler,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Alicyclobacillus metabolism MeSH
- Anti-Bacterial Agents biosynthesis MeSH
- Butyrates metabolism MeSH
- Ivermectin analogs & derivatives metabolism MeSH
- Pentanoic Acids metabolism MeSH
- Fatty Acids biosynthesis MeSH
- Rhodococcus metabolism MeSH
- Streptomyces metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
A biosynthetic pathway using pivalic acid as a starter unit was found in three bacterial species, Alicyclobacillus acidoterrestris, Rhodococcus erythropolis and Streptomyces avermitilis. When deuterium-labelled pivalic acid was added to A. acidoterrestris and R. erythropolis nutrient media it was incorporated into fatty acids to give rise to tert-butyl fatty acids (t-FAs). In addition, in R. erythropolis, pivalic acid was transformed into two starter units, i.e. isobutyric and 2-methylbutyric acid, which served as precursors of corresponding iso-even FAs and anteiso-FAs. In S. avermitilis the biosynthesis also yielded all three branched FAs; apart from this pathway, both pivalic and 2-methylbutyric acids were incorporated into the antibiotic avermectin.
References provided by Crossref.org
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