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Genová terapie: kationové lipidy pro konstrukci nevirálních vektorů nukleových kyselin
[Gene herapy: Cationic lipids for construction of nonviral vectors of nucleic acids]
Lukáš Drašar a Miroslav Ledvina
Jazyk čeština Země Česko
- MeSH
- antisense DNA MeSH
- fluorescenční spektrometrie MeSH
- genetická terapie MeSH
- lidé MeSH
- lipidy MeSH
- liposomy MeSH
- regulace genové exprese u nádorů MeSH
- transfekce MeSH
- Check Tag
- lidé MeSH
Gene therapy is often used in clinical research. It is related to the delivery of nucleic acids and their components to patient by a vector. Most current vector techniques can be divided into viral and nonviral. Nonviral vectors, such as cationic liposomes, are less toxic, less immunogenic, and easier to prepare than viral vectors. Hence they are more attractive for clinical applications. This review focuses on the relations between the cationic lipid structure and its transfection activity. To understand the structure-activity relationships is of great importance for synthesis of novel cationic lipids.
Ústav chemie přírodních látek Fakulta potravinářské chemie a biochemie VŠCHT Praha
Ústav organické chemie a biochemie AVČR v v i Flemingovo nám 1 166 28 Praha
Gene herapy: Cationic lipids for construction of nonviral vectors of nucleic acids
Literatura
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