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Corylucinine, a new alkaloid from Corydalis cava (Fumariaceae), and its cholinesterase activity
Z. Novák, J. Chlebek, L. Opletal, P. Jiros, K. Macáková, J. Kunes, L. Cahlíková
Natural product communications.
2012 ;
7 (7) :
859-860.
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc12034425
- MeSH
- acetylcholinesterasa metabolismus MeSH
- aktivace enzymů účinky léků MeSH
- alkaloidy chemie farmakologie MeSH
- butyrylcholinesterasa metabolismus MeSH
- cholinesterasové inhibitory chemie farmakologie MeSH
- cholinesterasy metabolismus MeSH
- Corydalis chemie MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
A new benzyldihydroisoquinoline alkaloid (1) was isolated from the tubers of Corydalis cava and named corylucinine. Additionally, 8-trichloromethyl-7,8-dihydropalmatine (2), an isolation artifact of tetrahydropalmatine, was obtained. The structures were established by spectroscopic (including 2D NMR and optical rotation) and HR-ESI-MS methods. Both compounds were tested for human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity. In comparison with the used standards, both compounds showed only moderate inhibitory activity against HuAChE (IC50,. HuAChE = 127.6 +/- 5.2 microM for 1, and IC50, HuAChE = 82.9 +/- 3.9 microM for 2) and none against HuBuChE.
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- $a Novák, Z. $7 _AN077759 $u Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, , 500 05 Hradec Králové, Czech Republic
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- $a Corylucinine, a new alkaloid from Corydalis cava (Fumariaceae), and its cholinesterase activity / $c Z. Novák, J. Chlebek, L. Opletal, P. Jiros, K. Macáková, J. Kunes, L. Cahlíková
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- $a A new benzyldihydroisoquinoline alkaloid (1) was isolated from the tubers of Corydalis cava and named corylucinine. Additionally, 8-trichloromethyl-7,8-dihydropalmatine (2), an isolation artifact of tetrahydropalmatine, was obtained. The structures were established by spectroscopic (including 2D NMR and optical rotation) and HR-ESI-MS methods. Both compounds were tested for human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity. In comparison with the used standards, both compounds showed only moderate inhibitory activity against HuAChE (IC50,. HuAChE = 127.6 +/- 5.2 microM for 1, and IC50, HuAChE = 82.9 +/- 3.9 microM for 2) and none against HuBuChE.
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- $a Chlebek, Jakub $7 _AN044625 $u Department of Pharmaceutical Botany and Ecology, Faculty ofPharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Krâlové, Czech Republic
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