Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

A prospective study in children with a severe form of atopic dermatitis: clinical outcome in relation to cytokine gene polymorphisms

Kayserova J., Sismova K., Zentsova-Jaresova I., Katina S., Vernerova E., Polouckova A., Capkova S., Malinova V., Striz I., Sediva A.

. 2012 ; 22 (2) : 92-101.

Language English Country Spain

Document type Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc12034554

BACKGROUND AND OBJECTIVE: The course of atopic dermatitis (AD) in childhood is characterized by typical changes in phenotype, including a shift from skin involvement to respiratory allergy usually around the third year of age. We thus designed a prospective study to monitor the outcome of severe AD and to investigate the association between cytokine gene polymorphisms and clinical manifestations. METHODS: Clinical and laboratory follow-up of 94 patients with severe AD and 103 healthy controls was performed using routine methodology. Allele, genotype, and haplotype frequencies of single nucleotide polymorphisms of 13 selected cytokine/receptor genes were analyzed using PCR with sequence-specific primers. RESULTS: In our study, genotypes of 7 polymorphisms--LL-4 -1098G/T and -590C/T, IL-6 -174C/G and nt565A/G, and IL-10 -1082A/G, -819C/T, and -592A/C were significantly associated with atopic AD (P < .05). A significant association was also found for TNF-alpha AA and IL-4 GC haplotypes and AD. We confirm the progressive clinical improvement of AD together with a decrease in the severity index SCORAD (SCORing atopic dermatitis) during childhood (P < .05). We found significant differences between IL-4Ralpha +1902 A/G and positivity of tree pollen-specific IgE (P < .05) in the AD group. Moreover, a weak association was also found between IL-10 -819C/T and IL-10 -590A/C and the appearance of allergic rhinitis (P < 0.1). CONCLUSIONS: We confirmed a clinical shift in allergic phenotype in the first 3 years of life, and showed an association between IL-4, IL-6, and IL-10 polymorphisms and AD. Our data indicate that IL-4alpha and IL-10 polymorphisms may be considered predictive factors of respiratory allergy in children with AD.

000      
00000naa a2200000 a 4500
001      
bmc12034554
003      
CZ-PrNML
005      
20160818062128.0
007      
ta
008      
121023s2012 sp f 000 0|eng||
009      
AR
035    __
$a (PubMed)22533231
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sp
100    1_
$a Kayserová, Jana, $d 1978- $7 xx0118295 $u Department of Immunology, Charles University, 2nd Faculty of Medicine, University Hospital Motol, Prague, Czech Republic
245    12
$a A prospective study in children with a severe form of atopic dermatitis: clinical outcome in relation to cytokine gene polymorphisms / $c Kayserova J., Sismova K., Zentsova-Jaresova I., Katina S., Vernerova E., Polouckova A., Capkova S., Malinova V., Striz I., Sediva A.
520    3_
$a BACKGROUND AND OBJECTIVE: The course of atopic dermatitis (AD) in childhood is characterized by typical changes in phenotype, including a shift from skin involvement to respiratory allergy usually around the third year of age. We thus designed a prospective study to monitor the outcome of severe AD and to investigate the association between cytokine gene polymorphisms and clinical manifestations. METHODS: Clinical and laboratory follow-up of 94 patients with severe AD and 103 healthy controls was performed using routine methodology. Allele, genotype, and haplotype frequencies of single nucleotide polymorphisms of 13 selected cytokine/receptor genes were analyzed using PCR with sequence-specific primers. RESULTS: In our study, genotypes of 7 polymorphisms--LL-4 -1098G/T and -590C/T, IL-6 -174C/G and nt565A/G, and IL-10 -1082A/G, -819C/T, and -592A/C were significantly associated with atopic AD (P < .05). A significant association was also found for TNF-alpha AA and IL-4 GC haplotypes and AD. We confirm the progressive clinical improvement of AD together with a decrease in the severity index SCORAD (SCORing atopic dermatitis) during childhood (P < .05). We found significant differences between IL-4Ralpha +1902 A/G and positivity of tree pollen-specific IgE (P < .05) in the AD group. Moreover, a weak association was also found between IL-10 -819C/T and IL-10 -590A/C and the appearance of allergic rhinitis (P < 0.1). CONCLUSIONS: We confirmed a clinical shift in allergic phenotype in the first 3 years of life, and showed an association between IL-4, IL-6, and IL-10 polymorphisms and AD. Our data indicate that IL-4alpha and IL-10 polymorphisms may be considered predictive factors of respiratory allergy in children with AD.
650    _2
$a alely $7 D000483
650    _2
$a studie případů a kontrol $7 D016022
650    _2
$a předškolní dítě $7 D002675
650    _2
$a atopická dermatitida $x genetika $7 D003876
650    _2
$a progrese nemoci $7 D018450
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a následné studie $7 D005500
650    _2
$a frekvence genu $7 D005787
650    _2
$a genetická predispozice k nemoci $7 D020022
650    _2
$a genotyp $7 D005838
650    _2
$a haplotypy $x genetika $7 D006239
650    _2
$a lidé $7 D006801
650    _2
$a kojenec $7 D007223
650    _2
$a novorozenec $7 D007231
650    _2
$a interleukiny $x genetika $7 D007378
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a jednonukleotidový polymorfismus $7 D020641
650    _2
$a prospektivní studie $7 D011446
650    _2
$a sezónní alergická rýma $x genetika $7 D006255
650    _2
$a TNF-alfa $x genetika $7 D014409
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Zentsová-Jarešová, Irena $7 xx0102059 $u Department of Immunology, Charles University, 2nd Faculty of Medicine, University Hospital Motol, Prague, Czech Republic
700    1_
$a Katina, Stanislav, $d 1976- $7 mub2013785208 $u Department of Applied Mathematics and Statistics, Faculty of Mathematics, Physics and Informatics, Comenius University, Bratislava, Slovakia; Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovakia
700    1_
$a Vernerová, Eva, $d 1951- $7 xx0063462 $u Department of Immunology, Charles University, 2nd Faculty of Medicine, University Hospital Motol, Prague, Czech Republic
700    1_
$a Poloučková, Andrea, $d 1972- $7 xx0118289 $u Department of Immunology, Charles University, 2nd Faculty of Medicine, University Hospital Motol, Prague, Czech Republic
700    1_
$a Čapková, Štěpánka, $d 1950- $7 jn19990209108 $u Paediatric Department of Dermatology, Paediatric Outpatient Department, University Hospital Motol, Prague, Czech Republic
700    1_
$a Malinová, Věra $7 xx0105527 $u Department of Paediatrics and Adolescent Medicine, 1st Faculty of Medicine, General University Hospital, Prague, Czech Republic
700    1_
$a Stříž, Ilja, $d 1958- $7 jn20000402309 $u Department of Immunogenetics, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Šedivá, Anna, $d 1955- $7 xx0000191 $u Department of Immunology, Charles University, 2nd Faculty of Medicine, University Hospital Motol, Prague, Czech Republic
773    0_
$w MED00002755 $t Journal of investigational allergology & clinical immunology official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología $x 1018-9068 $g Roč. 22, č. 2 (2012), s. 92-101
856    41
$u https://pubmed.ncbi.nlm.nih.gov/22533231 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20121023 $b ABA008
991    __
$a 20160818062422 $b ABA008
999    __
$a ok $b bmc $g 956564 $s 792051
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2012 $b 22 $c 2 $d 92-101 $i 1018-9068 $m Journal of investigational allergology & clinical immunology $n J Investig Allergol Clin Immunol $x MED00002755
LZP    __
$b NLK122 $a Pubmed-20121023

Find record

Citation metrics

Archiving options