Since the placenta is being continuously remodeled during normal placental development, extracellular nucleic acids of both fetal and placental origin, packed into either trophoblast-derived apoptotic bodies or shedding syncytiotrophoblast microparticles, may be detected in maternal circulation during the course of normal gestation. Placental-insufficiency-related pregnancy complications have been shown to be associated with excessive placental trophoblast apoptosis and shedding of placenta debris. Recent advances in the field are reviewed with a focus on the diagnostic potential of particular molecular biomarkers and their eventual implementation in the currently used predictive and diagnostic algorithms for placental-insufficiency-related pregnancy complications.

Department of Molecular Biology and Cell Pathology 3rd Faculty of Medicine Charles University Prague Prague 10 Czech Republic

000      

00000naa a2200000 a 4500

001      

bmc12034708

003      

CZ-PrNML

005      

20121207094558.0

007      

ta

008      

121023s2012 xxu f 000 0|eng||

009      

AR

024    7_

$a 10.1089/dna.2011.1530 $2 doi

035    __

$a (PubMed)22364204

040    __

$a ABA008 $b cze $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a xxu

100    1_

$a Hromadnikova, Ilona $u Department of Molecular Biology and Cell Pathology, Third Faculty of Medicine, Charles University in Prague, Prague 10, Czech Republic. ilona.hromadnikova@lf3.cuni.cz

245    10

$a Extracellular nucleic acids in maternal circulation as potential biomarkers for placental insufficiency / $c I. Hromadnikova,

520    9_

$a Since the placenta is being continuously remodeled during normal placental development, extracellular nucleic acids of both fetal and placental origin, packed into either trophoblast-derived apoptotic bodies or shedding syncytiotrophoblast microparticles, may be detected in maternal circulation during the course of normal gestation. Placental-insufficiency-related pregnancy complications have been shown to be associated with excessive placental trophoblast apoptosis and shedding of placenta debris. Recent advances in the field are reviewed with a focus on the diagnostic potential of particular molecular biomarkers and their eventual implementation in the currently used predictive and diagnostic algorithms for placental-insufficiency-related pregnancy complications.

650    _2

$a biologické markery $x krev $7 D015415

650    _2

$a DNA $x krev $7 D004247

650    _2

$a extracelulární prostor $x genetika $7 D005110

650    _2

$a ženské pohlaví $7 D005260

650    _2

$a lidé $7 D006801

650    _2

$a matky $7 D009035

650    _2

$a placentární insuficience $x krev $x diagnóza $x genetika $x patologie $7 D010927

650    _2

$a těhotenství $7 D011247

650    _2

$a RNA $x krev $7 D012313

655    _2

$a časopisecké články $7 D016428

655    _2

$a práce podpořená grantem $7 D013485

655    _2

$a přehledy $7 D016454

773    0_

$w MED00007256 $t DNA and cell biology $x 1557-7430 $g Roč. 31, č. 7 (2012), s. 1221-32

856    41

$u https://pubmed.ncbi.nlm.nih.gov/22364204 $y Pubmed

910    __

$a ABA008 $b sig $c sign $y a

990    __

$a 20121023 $b ABA008

991    __

$a 20121207094632 $b ABA008

999    __

$a ok $b bmc $g 956718 $s 792205

BAS    __

$a 3

BAS    __

$a PreBMC

BMC    __

$a 2012 $b 31 $c 7 $d 1221-32 $i 1557-7430 $m DNA and cell biology $n DNA Cell Biol $x MED00007256

LZP    __

$a Pubmed-20121023