-
Je něco špatně v tomto záznamu ?
Correlation between common genetic variants and risk factors associated with prediction of cardiovascular diseases in dyslipidemic patients
K. Kotaska, J. Kolarova, K. Kotrcova, J. Cepova, R. Prusa
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
PubMed
21919778
DOI
10.1089/gtmb.2011.0129
Knihovny.cz E-zdroje
- MeSH
- angiotensin konvertující enzym genetika MeSH
- dospělí MeSH
- dyslipidemie genetika MeSH
- genetická predispozice k nemoci MeSH
- genetická variace MeSH
- genotyp MeSH
- kardiovaskulární nemoci genetika MeSH
- kouření genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mutace MeSH
- polymorfismus genetický MeSH
- prediktivní hodnota testů MeSH
- rizikové faktory MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- synthasa oxidu dusnatého, typ III genetika MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
AIMS: The aim of the study was to investigate genetic variants predicting cardiovascular events in patients with dyslipidemia and compare its relationship with common risk factors including hyperlipidemia, metabolic syndrome, history of acute myocardial infarction, thrombosis, obesity, and smoking. MATERIALS AND METHODS: Five hundred two individuals divided into six groups corresponding with the risk factors and a control group of normolypidemic patients were analyzed for the presence of eight mutations and polymorphisms (endothelial nitric oxide synthase -786T → C and G894T; lymphotoxin A C804A; angiotensin-converting enzyme [ACE] ins/del; human platelet antigen 1 a/b; beta-fibrinogen -455G → A; apolipoprotein B [ApoB] R3500Q; APOE E2/E3/E4) using the ViennaLab CVD Strip assay. RESULTS: ACE deletions are the most frequent genetic variants in risk groups of dyslipidemic patients (from 58% in cardiovascular events to 51% in smokers). We found a strong relationship between genetic variants and risk factors. G894T is significantly associated with smoking (value of odds ratio [OR] = 1.62, p = 0.04), and ACE deletions are negatively associated with cardiovascular events (OR = 0.62, p = 0.03). CONCLUSION: Significant associations between genetic variants predicting cardiovascular events and common risk factors in dyslipidemic patients were found.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc12034901
- 003
- CZ-PrNML
- 005
- 20160729152029.0
- 007
- ta
- 008
- 121023s2012 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1089/gtmb.2011.0129 $2 doi
- 035 __
- $a (PubMed)21919778
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Kotaška, Karel $7 xx0036857 $u Department of Clinical Biochemistry and Pathobiochemistry, 2nd Faculty of Medicine, Charles University, Faculty Hospital Motol, Prague, Czech Republic. kotaska@email.cz
- 245 10
- $a Correlation between common genetic variants and risk factors associated with prediction of cardiovascular diseases in dyslipidemic patients / $c K. Kotaska, J. Kolarova, K. Kotrcova, J. Cepova, R. Prusa
- 520 9_
- $a AIMS: The aim of the study was to investigate genetic variants predicting cardiovascular events in patients with dyslipidemia and compare its relationship with common risk factors including hyperlipidemia, metabolic syndrome, history of acute myocardial infarction, thrombosis, obesity, and smoking. MATERIALS AND METHODS: Five hundred two individuals divided into six groups corresponding with the risk factors and a control group of normolypidemic patients were analyzed for the presence of eight mutations and polymorphisms (endothelial nitric oxide synthase -786T → C and G894T; lymphotoxin A C804A; angiotensin-converting enzyme [ACE] ins/del; human platelet antigen 1 a/b; beta-fibrinogen -455G → A; apolipoprotein B [ApoB] R3500Q; APOE E2/E3/E4) using the ViennaLab CVD Strip assay. RESULTS: ACE deletions are the most frequent genetic variants in risk groups of dyslipidemic patients (from 58% in cardiovascular events to 51% in smokers). We found a strong relationship between genetic variants and risk factors. G894T is significantly associated with smoking (value of odds ratio [OR] = 1.62, p = 0.04), and ACE deletions are negatively associated with cardiovascular events (OR = 0.62, p = 0.03). CONCLUSION: Significant associations between genetic variants predicting cardiovascular events and common risk factors in dyslipidemic patients were found.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a kardiovaskulární nemoci $x genetika $7 D002318
- 650 _2
- $a dyslipidemie $x genetika $7 D050171
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a genetická predispozice k nemoci $7 D020022
- 650 _2
- $a genetická variace $7 D014644
- 650 _2
- $a genotyp $7 D005838
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a mutace $7 D009154
- 650 _2
- $a synthasa oxidu dusnatého, typ III $x genetika $7 D052250
- 650 _2
- $a angiotensin konvertující enzym $x genetika $7 D007703
- 650 _2
- $a polymorfismus genetický $7 D011110
- 650 _2
- $a prediktivní hodnota testů $7 D011237
- 650 _2
- $a rizikové faktory $7 D012307
- 650 _2
- $a kouření $x genetika $7 D012907
- 650 _2
- $a mladý dospělý $7 D055815
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Kolářová, Jitka $7 _BN006925 $u Department of Clinical Biochemistry and Pathobiochemistry, University Hospital Motol and Charles University, 2nd Faculty of Medicine, Prague, Czech Republic
- 700 1_
- $a Kotrčová, K. $7 _AN047520 $u Department of Clinical Biochemistry and Pathobiochemistry, University Hospital Motol and Charles University, 2nd Faculty of Medicine, Prague, Czech Republic
- 700 1_
- $a Čepová, Jana, $d 1966- $7 xx0002160 $u Department of Clinical Biochemistry and Pathobiochemistry, University Hospital Motol and Charles University, 2nd Faculty of Medicine, Prague, Czech Republic
- 700 1_
- $a Průša, Richard, $d 1962- $7 nlk19990073743 $u Department of Clinical Biochemistry and Pathobiochemistry, University Hospital Motol and Charles University, 2nd Faculty of Medicine, Prague, Czech Republic
- 773 0_
- $w MED00174670 $t Genetic testing and molecular biomarkers $x 1945-0257 $g Roč. 16, č. 3 (2012), s. 210-214
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/21919778 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20121023 $b ABA008
- 991 __
- $a 20160729151831 $b ABA008
- 999 __
- $a ok $b bmc $g 956911 $s 792398
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2012 $b 16 $c 3 $d 210-214 $i 1945-0257 $m Genetic testing and molecular biomarkers $n Genet Test Mol Biomarkers $x MED00174670
- LZP __
- $b NLK112 $a Pubmed-20121023
