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An antagonist of GABA-B receptors potentiates activity of cortical epileptic foci
P. Mareš, K. Bernášková, H. Kubová
Language English Country Czech Republic
Document type Journal Article, Research Support, Non-U.S. Gov't
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- MeSH
- GABA-B Receptor Antagonists toxicity MeSH
- Bicuculline analogs & derivatives MeSH
- Time Factors MeSH
- Electroencephalography MeSH
- Epilepsy chemically induced metabolism physiopathology MeSH
- Rats MeSH
- Disease Models, Animal MeSH
- Cerebral Cortex metabolism physiopathology drug effects MeSH
- Brain Waves drug effects MeSH
- Organophosphorus Compounds toxicity MeSH
- Rats, Wistar MeSH
- Reaction Time drug effects MeSH
- Receptors, GABA-B metabolism drug effects MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Cortical epileptic foci elicited by local application of bicuculline methiodide represent a model of interictal epileptic activity with a transition into ictal phases. We studied a role of GABA-B receptors in this model using GABA-B receptor antagonist CGP35348 in adult rats with implanted cortical electrodes and cannula. CGP35348 (100 or 200 mg/kg i.p.) did not affect interictal discharges but it augmented ictal activity. Latency to the first ictal episode was decreased by the lower dose of CGP35348, duration of episodes was increased by the higher dose. GABA-B receptor antagonist did not influence purely cortical epileptic phenomenon but it is proconvulsant in ictal activity generated with participation of subcortical structures.
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