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Cured malakoplakia of the renal allograft followed by long-term good function: a case report
E. Honsova, A. Lodererova, J. Slatinska, P. Boucek
Language English Country Czech Republic
Document type Journal Article, Research Support, Non-U.S. Gov't, Case Reports
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- MeSH
- Anti-Bacterial Agents therapeutic use MeSH
- Quinolones therapeutic use MeSH
- Diabetes Mellitus, Type 1 surgery MeSH
- Adult MeSH
- Humans MeSH
- Malacoplakia diagnosis etiology drug therapy MeSH
- Kidney Diseases etiology drug therapy MeSH
- Kidney Transplantation adverse effects MeSH
- Pancreas Transplantation MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: Malakoplakia is an unusual chronic inflammatory disease with distinctive histopathological features rarely involving the parenchyma of a transplanted kidney, and to date less than ten cases have been reported. METHODS AND RESULTS: We present a case of malakoplakia of a kidney graft in a 31 year old woman after simultaneous kidney and pancreas transplantation, which was successfully treated with quinolones. After the treatment of malakoplakia, she was monitored regularly, and her renal and pancreas grafts functioned well for the following 9 years, which is 12 years post transplantation. Moreover, 1 year after treatment of malakoplakia she became pregnant and gave birth to a healthy child. CONCLUSION: Evaluation of a kidney biopsy sample represents the key to diagnosis of malakoplakia which is important for correct patient management. Treatment with antibiotics with intracellular penetration (quinolone type) may result in curing the disease. According to our knowledge, this is the first case of allograft renal malakoplakia after combined kidney and pancreas transplantation.
Department of Nephrology Institute for Clinical and Experimental Medicine Prague
Diabetes Centre Institute for Clinical and Experimental Medicine Prague
References provided by Crossref.org
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- $a BACKGROUND: Malakoplakia is an unusual chronic inflammatory disease with distinctive histopathological features rarely involving the parenchyma of a transplanted kidney, and to date less than ten cases have been reported. METHODS AND RESULTS: We present a case of malakoplakia of a kidney graft in a 31 year old woman after simultaneous kidney and pancreas transplantation, which was successfully treated with quinolones. After the treatment of malakoplakia, she was monitored regularly, and her renal and pancreas grafts functioned well for the following 9 years, which is 12 years post transplantation. Moreover, 1 year after treatment of malakoplakia she became pregnant and gave birth to a healthy child. CONCLUSION: Evaluation of a kidney biopsy sample represents the key to diagnosis of malakoplakia which is important for correct patient management. Treatment with antibiotics with intracellular penetration (quinolone type) may result in curing the disease. According to our knowledge, this is the first case of allograft renal malakoplakia after combined kidney and pancreas transplantation.
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