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Mammalian metallothioneins: properties and functions
P. Babula, M. Masarik, V. Adam, T. Eckschlager, M. Stiborova, L. Trnkova, H. Skutkova, I. Provaznik, J. Hubalek, R. Kizek,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
22791193
DOI
10.1039/c2mt20081c
Knihovny.cz E-zdroje
- MeSH
- apoptóza MeSH
- chemorezistence MeSH
- glutathion metabolismus MeSH
- kadmium metabolismus MeSH
- kovy metabolismus MeSH
- lidé MeSH
- metalothionein chemie metabolismus MeSH
- molekulární modely MeSH
- molekulární sekvence - údaje MeSH
- nádory farmakoterapie MeSH
- proliferace buněk MeSH
- protinádorové látky farmakologie MeSH
- sekvence aminokyselin MeSH
- volné radikály metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective effects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc(II) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.
Citace poskytuje Crossref.org
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