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Distribution of nuclear receptors for steroid hormones in the human brain: a preliminary study
M. Bezdickova, R. Molikova, L. Bebarova, Z. Kolar
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články, práce podpořená grantem
Free Medical Journals od 1998
Medline Complete (EBSCOhost) od 2007-06-01
ROAD: Directory of Open Access Scholarly Resources od 2001
- MeSH
- dospělí MeSH
- imunohistochemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mozek metabolismus MeSH
- receptory cytoplazmatické a nukleární metabolismus MeSH
- senioři MeSH
- steroidní receptory metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: Expression of the nuclear steroid hormone receptors (SHR) within certain parts of the human brain has been described by many authors. However, a comprehensive analysis of SHR expression in the human brain still has not been performed. AIM: To investigate the expression of SHR in different anatomical areas of the brain, especially within the neocortex. METHOD: Immunohistochemical expression of estrogen receptors (ER), progesterone receptors (PR) and androgen receptors (AR) in different regions of the human brain was examined. RESULTS: Nuclear expression of the AR was found in the mamillary body, praecentral gyrus and hippocampus of males. The same expression in analysed structures of female was not found. The expression of ER and PR was not observed. CONCLUSIONS: The analysis revealed unexpected localization of SHR within the brain cortex, which could be the first step to the explanation of SHR action in brain as an interrelationship to function and behaviour. These results indicate on the possibility of SHR detection in post-mortal brain.
Department of Anatomy Faculty of Medicine and Dentistry Palacký University Olomouc
Department of Pathology Faculty of Medicine and Dentistry Palacky University Olomouc
Laboratory of Molecular Pathology Faculty of Medicine and Dentistry Palacky University Olomouc
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- $a Bezdičková, Marcela, $d 1975- $7 mzk2007411119 $u Department of Anatomy, Faculty of Medicine and Dentistry, Palacký University, Olomouc; Laboratory of Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University, Olomouc
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- $a Distribution of nuclear receptors for steroid hormones in the human brain: a preliminary study / $c M. Bezdickova, R. Molikova, L. Bebarova, Z. Kolar
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- $a BACKGROUND: Expression of the nuclear steroid hormone receptors (SHR) within certain parts of the human brain has been described by many authors. However, a comprehensive analysis of SHR expression in the human brain still has not been performed. AIM: To investigate the expression of SHR in different anatomical areas of the brain, especially within the neocortex. METHOD: Immunohistochemical expression of estrogen receptors (ER), progesterone receptors (PR) and androgen receptors (AR) in different regions of the human brain was examined. RESULTS: Nuclear expression of the AR was found in the mamillary body, praecentral gyrus and hippocampus of males. The same expression in analysed structures of female was not found. The expression of ER and PR was not observed. CONCLUSIONS: The analysis revealed unexpected localization of SHR within the brain cortex, which could be the first step to the explanation of SHR action in brain as an interrelationship to function and behaviour. These results indicate on the possibility of SHR detection in post-mortal brain.
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