• Something wrong with this record ?

Polyamine conjugates of stigmasterol

N. Vida, H. Svobodová, L. Rárová, P. Drašar, D. Saman, J. Cvačka, Z. Wimmer,

. 2012 ; 77 (12) : 1212-8.

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc13012573

Three new polyamine conjugates with stigmasterol [(3β,22E)-stigmasta-5,22-dien-3-ol] were synthesized and subjected to basic antimicrobial and cytotoxic tests. The conjugate derived from spermine, (3β,22E)-stigmasta-5,22-dien-3-yl 4(12-amino-4,9-diaza-dodecylamino)-4-oxobutanoate (5c), displayed considerable antimicrobial activity on Staphylococcus aureus at low concentration (50 μg mL(-1)). The cytotoxic activity was tested on cells of human T-lymfoblastic leukemia (IC(50)=35.8 ± 10.3 μM (5c) and IC(50)=35.9 ± 5.7 μM (5b)) and normal human fibroblasts (IC(50)=38.0 ± 2.8 μM (5c) and IC(50)=45.5 ± 1.9 μM (5b)). Conjugate 5a displayed no activity in both tests.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc13012573
003      
CZ-PrNML
005      
20130412111125.0
007      
ta
008      
130404s2012 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.steroids.2012.07.009 $2 doi
035    __
$a (PubMed)22850319
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Vida, Norbert $u Institute of Chemical Technology, Faculty of Food and Biochemical Technology, Department of Chemistry of Natural Compounds, Technická 5, 16628 Prague 6, Czech Republic.
245    10
$a Polyamine conjugates of stigmasterol / $c N. Vida, H. Svobodová, L. Rárová, P. Drašar, D. Saman, J. Cvačka, Z. Wimmer,
520    9_
$a Three new polyamine conjugates with stigmasterol [(3β,22E)-stigmasta-5,22-dien-3-ol] were synthesized and subjected to basic antimicrobial and cytotoxic tests. The conjugate derived from spermine, (3β,22E)-stigmasta-5,22-dien-3-yl 4(12-amino-4,9-diaza-dodecylamino)-4-oxobutanoate (5c), displayed considerable antimicrobial activity on Staphylococcus aureus at low concentration (50 μg mL(-1)). The cytotoxic activity was tested on cells of human T-lymfoblastic leukemia (IC(50)=35.8 ± 10.3 μM (5c) and IC(50)=35.9 ± 5.7 μM (5b)) and normal human fibroblasts (IC(50)=38.0 ± 2.8 μM (5c) and IC(50)=45.5 ± 1.9 μM (5b)). Conjugate 5a displayed no activity in both tests.
650    _2
$a antibakteriální látky $x chemická syntéza $x chemie $x farmakologie $7 D000900
650    _2
$a protinádorové látky $x chemická syntéza $x chemie $x farmakologie $7 D000970
650    _2
$a kyseliny karboxylové $x chemie $7 D002264
650    _2
$a nádorové buněčné linie $7 D045744
650    _2
$a vztah mezi dávkou a účinkem léčiva $7 D004305
650    _2
$a racionální návrh léčiv $7 D015195
650    _2
$a lidé $7 D006801
650    _2
$a molekulární modely $7 D008958
650    _2
$a molekulární konformace $7 D008968
650    _2
$a chemické jevy $7 D055598
650    _2
$a polyaminy $x chemie $7 D011073
650    _2
$a Staphylococcus aureus $x účinky léků $7 D013211
650    _2
$a stigmasterol $x chemická syntéza $x chemie $x farmakologie $7 D013265
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Svobodová, Hana $u -
700    1_
$a Rárová, Lucie $u -
700    1_
$a Drašar, Pavel $u -
700    1_
$a Saman, David $u -
700    1_
$a Cvačka, Josef $u -
700    1_
$a Wimmer, Zdeněk $u -
773    0_
$w MED00004438 $t Steroids $x 1878-5867 $g Roč. 77, č. 12 (2012), s. 1212-8
856    41
$u https://pubmed.ncbi.nlm.nih.gov/22850319 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20130404 $b ABA008
991    __
$a 20130412111356 $b ABA008
999    __
$a ok $b bmc $g 975771 $s 810854
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2012 $b 77 $c 12 $d 1212-8 $i 1878-5867 $m Steroids $n Steroids $x MED00004438
LZP    __
$a Pubmed-20130404

Find record

Citation metrics

Archiving options